Elsevier

Psychiatry Research

Volume 1, Issue 3, December 1979, Pages 249-254
Psychiatry Research

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

https://doi.org/10.1016/0165-1781(79)90006-4Get rights and content

Abstract

Abuse of 4-propyloxy-4-phenyl-N-methylpiperidine, a meperidine congener, produced parkinsonism in a 23-year-old man. Unlike other drug-induced motor disturbances, the syndrome perisited for 18 months and responded to drugs that stimulate dopamine receptors. Biogenic amines and metabolites in the cerebrospinal fluid and microscopic evaluation of the brain at necropsy were consistent with damage to aminergic neurons in the substantia nigra.

References (4)

  • L. Berger et al.

    Piperidine derivatives: Part IV. 4-Alkyl-4- and 4-hetero-cyclyl-piperidines

    Journal of Organic Chemistry

    (1947)
  • E.D. Caine et al.

    An outline for the analysis of dementia

    Neurology

    (1977)
There are more references available in the full text version of this article.

Cited by (1185)

  • Mitochondria in neurodegeneration

    2022, Current Opinion in Physiology
View all citing articles on Scopus

The authors would like to acknowledge Dr. M. Valsamis, neuropathologist, Dr. V. Dolan of the Medical Examiner's Office, Baltimore, MD, and Mr. R.I. Eisenberg for photography.

View full text