Components of the opioid withdrawal syndrome in mice are thermoregulatory responses
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Opioid withdrawal behavior in spiny mice: A novel preclinical model of neonatal opioid withdrawal syndrome (NOWS)
2021, HeliyonCitation Excerpt :While changes in body temperature have not been well characterized in rodent models of NOWS, a 2019 study showed that body temperature decreased following prenatal opioid exposure (Wallin et al., 2019). Additionally, studies in adult rodent models of opioid withdrawal have also reported a decrease in body temperature (Belknap, 1989; Lipták et al., 2012). In contrast to these previous reports, the body temperature of spiny mice pups from the morphine exposed groups was significantly higher in both sexes.
Sex differences in the expression of morphine withdrawal symptoms and associated activity in the tail of the ventral tegmental area
2019, Neuroscience LettersCitation Excerpt :The second greatest sex difference in withdrawal symptoms, in the present study occurred as the expression of wet-dog shakes. Wet-dog shakes occur as a part of the withdrawal syndrome, a condition that develops as the result of hypothermia [40]. Sex differences in wet-dog shakes were previously reported [30] and attributed to established sex differences in morphine-induced hypothermia [41].
Genetic correlates of morphine withdrawal in 14 inbred mouse strains
2009, Drug and Alcohol DependenceSex differences in thermoregulation after acute and chronic morphine administration in mice
2000, Neuroscience LettersGenetic determinants of morphine activity and thermal responses in 15 inbred mouse strains
1998, Pharmacology Biochemistry and BehaviorHypothermic effects of neuropeptide FF analogues in mice
1997, Pharmacology Biochemistry and Behavior