ArticleFlight behavior induced by microinjection of GABA antagonists into periventricular structures in detelencephalated rats☆
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2019, Biological PsychiatryCitation Excerpt :Moreover, in the perspective of recent work identifying the complex and tightly controlled CeA microcircuits that contribute to fear learning (64,65), these results may also indicate a functional role of AT2R-CeM cells that extends beyond that of simply gating the behavioral and endocrine responses during conditioned threat exposure. Numerous lesioning (66–68) and pharmacological (69–71) studies have identified the PAG as an essential site of converging signals regulating flight and freezing responses, and input to the PAG from regions such as the CeA has been recently shown to mediate freezing through disinhibition of ventrolateral PAG outputs to the medulla (72). Given the necessity of CeA-PAG connectivity to orchestrate adaptive behavioral responses, we targeted the PAG with the retrograde tracer CTB to determine whether it receives direct AT2R+-GABAergic input.
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2005, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Thus, while submission clearly involves integration of aversive information in higher brain structures, defense does not require this refinement. Indeed, it has been shown that escape behavior is still induced by MT stimulation in thalamic rats (Tomaz et al., 1988). Adams (1979) suggested that the ventromedial nucleus of the hypothalamus, which interconnects heavily with the amygdala, seems to possess a mechanism that switches the behavior of an animal from defense to submission in particularly dangerous situations.
Flight reactions to nitric oxide in the inferior colliculus of rats depend on NMDA receptor activation
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This research was carried out at the Laboratoire de Neurophysiologie, Centre de Neurochimie du CNRS-5, Strasourg, France.