Cross-tolerance between Δ9-tetrahydrocannabinol and ethanol: The role of drug disposition
References (32)
- et al.
Drug metabolism in ethanol induced fatty liver
Life Sci.
(1970) - et al.
Significance in vivo of the increase in microsomal ethanol-oxidizing system after chronic administration of ethanol, phenobarbital and chlorcyclizine
Biochem. Pharmac.
(1972) - et al.
Effect of chronic ethanol treatment on metabolism of drugs in vitro and in vivo
Biochem. Pharmac.
(1976) - et al.
Studies on the effects of Δ1-THC and DDT on the hepatic microsomal metabolism of Δ1-THC and other compounds in the rat
Chem. Biol. Interact.
(1973) - et al.
Hepatic microsomal ethanol oxidizing system: In vitro characteristics and adaptive properties in vivo
J. Biol. Chem.
(1970) Duration of the enhanced activity of the microsomal ethanol-oxidizing enzyme system and rate of ethanol degradation in ethanol-fed rats after withdrawal
Biochem. Pharmac.
(1972)- et al.
Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and rats
Am. J. Med.
(1971) - et al.
Metabolism of Δ1-tetrahydrocannabinol by the rat in vivo and in vitro
Biochem. Pharmac.
(1975) - et al.
Effect of cannabis on pentobarbital-induced sleeping time and penbarbital metabolism in the rat
Biochem. Pharmac.
(1974) - et al.
Ethanol and delta-9-tetrahydrocannabinol: Mechanism for cross-tolerance inmice
Pharmac. Biochem. Behav.
(1976)
Development and loss of tolerance to ethanol in goldfish
J. Pharmacol. exp. Ther.
The ultrastructure of fatty liver induced by prolonged ethanol ingestion
Am. J. Pathol.
Clinical studies of cannabis tolerance and dependence
Ann. N.Y. Acad. Sci.
Psychological studies of marijuana and alcohol in man
Psychopharmacologia
Effect of acute and chronic pretreatment with Δ9-tetrahydrocannabinol on motor impairement by ethanol in the rat
Can. J. Physiol. Pharmac.
Cited by (25)
THC inhibits the expression of ethanol-induced locomotor sensitization in mice
2017, AlcoholCitation Excerpt :In the present study, no cannabinoid antagonist was used; there is no evidence that THC in the dose and period of treatment used here induced withdrawal effects in rodents. The decreased locomotor activity observed in the THC-treated group may be explained by a cross-tolerance effect, as previously described in the literature (Dar, 2014; Pava & Woodward, 2012; Siemens & Doyle, 1979; Sprague & Craigmill, 1976). Chronic THC can decrease the acute ataxic effect of ethanol, and chronic ethanol can decrease the acute THC hypolocomotor effect (Pava & Woodward, 2012).
The Role of the Endocannabinoid System in Addiction
2017, The Endocannabinoid System: Genetics, Biochemistry, Brain Disorders, and TherapyFunctional interaction and cross-tolerance between ethanol and δ<sup>9</sup>-THC: Possible modulation by mouse cerebellar adenosinergic A<inf>1</inf>/GABAergic-A receptors
2014, Behavioural Brain ResearchCitation Excerpt :The combined effect of ICB Δ9-THC and systemic alcohol administration, however, was found to be considerably worse on ataxia [3], and memory impairment [4] in mice and rats, respectively. Cross-tolerance between alcohol and Δ9-THC was reported in earlier studies [5,6], but the results were contradictory due to variability in experimental conditions. It has also been observed that the effect of alcohol is attenuated in humans using marijuana suggesting possible cross-tolerance between the two substances [7,8].
Cannabinoids and the Neural Actions of Alcohol
2014, Neurobiology of Alcohol DependenceA review of the interactions between alcohol and the endocannabinoid system: Implications for alcohol dependence and future directions for research
2012, AlcoholCitation Excerpt :Subsequent studies conducted in the 1970's demonstrate that cross-tolerance also arises between the ataxic effects of cannabinoids and ethanol (Siemens & Doyle, 1979; Sprague & Craigmill, 1976). This cross-tolerance was not due to pharmacokinetic processes because ethanol-tolerant subjects did not metabolize THC more readily, and THC-tolerant rats did not show increased turnover of ethanol (Siemens & Doyle, 1979). A more recent study demonstrates that a single dose of ethanol confers tolerance to a subsequent dose of THC, but pre-treatment with a single dose of THC facilitates the ataxic effect of acute ethanol (da Silva, Morato, & Takahashi, 2001).