Glycine receptor-mediated fast synaptic inhibition in the brainstem respiratory system
References (22)
- et al.
Localization of glycine receptors in the rat central nervous system: an immunohistochemical analysis using monoclonal antibody
Neuroscience
(1988) - et al.
Involvement of amino acids in periodic inhibitions of bulbar respiratory neurones
Brain Res.
(1982) - et al.
The effect of some depressing amino acids on bulbar respiratory and non-respiratory neurons
Brain Res.
(1975) - et al.
Effects of amino acids on the excitability of respiratory bulbospinal neurons in solitary and para-ambigual regions of medulla in cat
Brain Res.
(1988) - et al.
Respiratory depression produced by glycine injected into the cisterna magna of cats
Neuropharmacology
(1982) - et al.
Respiratory reflexes in an isolated brainstem-lung preparation of the newborn rat: possible involvement of gamma-aminobutyric acid and glycine
Neurosci. Lett.
(1985) - et al.
Cycle-triggered averaging of respiration-related neuronal activity
Comput. Methods Progr. Biomed.
(1985) - et al.
Involvement of fast synaptic inhibition in the generation of high-frequency oscillation in central respiratory system
Brain Res.
(1989) - et al.
Post-synaptic inhibition of bulbar inspiratory neurones in the cat
J. Physiol. (London)
(1984) Neurophysiology of breathing in mammals
Postsynaptic actions of inhibitory neurotransmitters on bulbar respiratory neurons
Cited by (60)
Respiratory rhythm and pattern generation: Brainstem cellular and circuit mechanisms
2022, Handbook of Clinical NeurologyProbing the function of glycinergic neurons in the mouse respiratory network using optogenetics
2019, Respiratory Physiology and NeurobiologyCitation Excerpt :Glycinergic inhibition is believed to be critical for the inspiration to post-inspiration, and late-expiration to inspiration phase transitions (Ausborn et al., 2018; Richter and Smith, 2014; Rybak et al., 2007; Shevtsova et al., 2014). Systemic or local pharmacological blockage of the glycinergic transmission within the ventral respiratory columns, was shown to disrupt the rhythm, de-stabilize the regularity and pattern of inspiration, and abolish post-I motor activity (Bongianni et al., 2010; Busselberg et al., 2001; Dutschmann and Paton, 2002a, b; Paton and Richter, 1995; Pierrefiche et al., 1998; Schmid et al., 1991). However, this view was challenged by Janczewski and colleagues, who showed that postsynaptic inhibition within the preBötC and BötC had little, if any, effect on the rhythm in vagotomised rats (Janczewski et al., 2013).
Glycine Receptor Drug Discovery
2017, Advances in PharmacologyCitation Excerpt :Inhibitory interactions between neurons of the brain stem respiratory network enable stable rhythmic breathing. A failure of glycinergic inhibitory transmission has been implicated in impairment of respiratory rhythm (Busselberg, Bischoff, Becker, Becker, & Richter, 2001; Pierrefiche, Schwarzacher, Bischoff, & Richter, 1998; Schmid, Bohmer, & Gebauer, 1991), which may lead to sudden death (Busselberg et al., 2001; Harvey et al., 2008; Markstahler, Kremer, Kimmina, Becker, & Richter, 2002). The rhythmic activity of this neuronal network is maintained by serotonin receptor type 1 receptor activation, which ensures that synaptic α3 GlyRs remain in a dephosphorylated, and thus maximally activated, state (Manzke et al., 2010).
Ethanol effects on glycinergic transmission: From molecular pharmacology to behavior responses
2015, Pharmacological ResearchCitation Excerpt :Furthermore, LGICs are targets of a wide range of chemical compounds. For example, several effects of ethanol on α1 GlyRs are believed to be relevant to human health because ethanol causes motor, respiratory and cardiovascular alterations [197–200], likely by altering these chloride currents [129,130,139]. Recent studies have demonstrated that agonists and antagonists of GlyRs affect the brain reward system [201].
Postnatal development of glycine receptor subunits α1, α2, α3, and β immunoreactivity in multiple brain stem respiratory-related nuclear groups of the rat
2013, Brain ResearchCitation Excerpt :Glycine is one of the two major inhibitory neurotransmitters in the central nervous system (Aprison and Daly, 1978). Like GABA, glycine is critical for fast synaptic inhibition in the brain stem respiratory system and is essential for normal respiratory pattern generation by controlling respiratory phase transitions during pre- and postinspiration in the neonate and in the adult (Schmid et al., 1991; Paton and Richter, 1995; Shao and Feldman, 1997; Büsselberg et al., 2001; Dutschmann and Paton, 2002). Although glycinergic pacemaker neurons have been found in the PBC (Morgado-Valle et al., 2010), they are few in number, and inhibition is considered not necessary for inspiratory rhythmogenesis in the PBC (Feldman et al., 2013).
Central respiratory failure during acute organophosphate poisoning
2013, Respiratory Physiology and Neurobiology