ArticleMotor activity correlates negatively with free-running period, while positively with serotonin contents in SCN in free-running rats
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Feedback actions of locomotor activity to the circadian clock
2012, Progress in Brain ResearchCitation Excerpt :The presence of a home-cage running wheel shortens tau in rats and mice (Benus et al., 1988; Edgar et al., 1991; Mistlberger and Holmes, 2000; Mistlberger et al., 1998; Yamada et al., 1986, 1988) and has been suggested, though not proven, to do so in hamsters (Pratt and Goldman, 1986; though see also Aschoff et al., 1973). In rats, the magnitude of tau shortening by wheel-running correlates with the number of wheel revolutions performed (Shioiri et al., 1991; Yamada et al., 1990), an effect also seen, though somewhat inconsistently, in hamsters (Mrosovsky, 1999; Weisgerber et al., 1997). To be of functional use for entrainment, however, feedback information from locomotor activity must demonstrate the ability to synchronize free-running rhythms through repeated phase adjustments when the opportunity to indulge in locomotor activity is either offered, induced, or forced repeatedly on sequential cycles.
Physiology of the Mammalian Circadian System
2010, Principles and Practice of Sleep Medicine: Fifth EditionFunctional neuroanatomy of sleep and circadian rhythms
2009, Brain Research ReviewsCitation Excerpt :Several studies have examined directly the potential role of serotonergic afferents to the circadian system in mediating the effects of behavioral arousal on the circadian pacemaker. Arousal, wakefulness and motor activity are all associated with increased forebrain serotonin release (Jacobs and Fornal, 1999), including in the SCN (Grossman et al., 2000; Mistlberger et al., 2000; Shioiri et al., 1991), and behavioral state-dependent serotonin release appears to at least partially mediate entrainment by scheduled daily locomotor activity and the effects of arousal on light-induced phase shifting (Edgar et al., 1997; Grossman et al., 2000; Marchant et al., 1997; Mistlberger and Antle, 1998; Mistlberger et al., 1998). In contrast, however, neither intra-SCN serotonin lesions, nor any of several serotonin receptor antagonists, inhibit circadian phase shifting by novelty-induced activity (Antle et al., 1998; Bobrzynska et al., 1996; Meyer-Bernstein and Morin, 1998).
MDMA alters the response of the mammalian circadian clock in hamsters: Effects on re-entrainment and triazolam-induced phase shifts
2005, Brain ResearchCitation Excerpt :Similar to MDMA, reserpine causes a reduction in the concentrations of serotonin, dopamine and nonadrenaline in the hypothalamus. These findings are consistent with previous studies showing that the serotonin content in the SCN is positively correlated with motor activity in rats [67]. In conclusion, our results illustrate the modulatory role of the serotonergic system in the regulation of the circadian clock and support previous findings on the ability of MDMA to alter the clock function.
Physiology of the Mammalian Circadian System
2005, Principles and Practice of Sleep MedicineLet there be "more" light: Enhancement of light actions on the circadian system through non-photic pathways
2004, Progress in Neurobiology