Elsevier

Physiology & Behavior

Volume 17, Issue 4, October 1976, Pages 645-649
Physiology & Behavior

VMH lesions and reactivity to electric footshock in the rat: The effect of early testosterone level

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Abstract

Reactivity to electric footshock before and after lesions in the ventromedial hypothalamic nucleus (VMH) was measured in neonatally castrated adult male rats and their gonadally intact adult female littermates. The sexual differentiation of the VMH for the control of aversive thresholds begins before birth, since neonatal castrates with no perinatal testosterone replacement had higher adult footshock thresholds than their female littermates and showed a male-typical VMH lesion effect on behavior. Masculinization of the VMH, however, is not complete at birth. A positive relationship was observed between the level of early testosterone and the extent of VMH lesion-induced behavioral change in adulthood: low and high testosterone levels in the first days of life produced quantitatively different VMH lesion effects on behavior.

References (10)

  • M. Dennis

    Sex-dependent and sex-independent neural control of reactivity to electric footshock in the rat

    Expl Neurol.

    (1972)
  • W.W. Beatty

    Hormonal determinants of sex differences in avoidance behavior and reactivity to electric shock

    Diss. Abstr. (B)

    (1970)
  • G. Doerner et al.

    Structural changes in the hypothalamic ventromedial nucleus of the male rat, following neonatal castration and androgen treatment

    Neuroendocrinology

    (1969)
  • J.A. Harvey et al.

    Lesions in the medial forebrain bundle: delayed effects on sensitivity to electric shock

    Science

    (1965)
  • W.E. Kappauf

    Final report on context effects in psychophysical judgments (Introduction and Part 1: The Up-and-Down Method)

There are more references available in the full text version of this article.

Cited by (4)

1

This report is based on a Ph.D. dissertation submitted to York University. The research was supported by National Research Council of Canada Grant Number APA314 to Bruno Kohn.

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