Theoretical reviewProducing and interpreting experimental olfactory deficits☆
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Cited by (157)
The olfactory bulbectomy disease model: A Re-evaluation.
2021, Physiology and BehaviorCitation Excerpt :Since disfunction in these brain areas is thought to underlie MDD, this view has been used to justify the use of the OBX rodent as a model of this complex disorder. The evidence supporting this canon is almost exclusively based on comparisons of the OBX procedure to a classic method of shutting off peripheral input by chemically destroying olfactory sensory neurons using ZnSO4 nasal cavity lavage, a process that has repeatedly failed to reproduce key behaviors of the OBX syndrome, including hyperactivity [4,6,7,50]. However, there are at least three major drawbacks with this technique that cast doubt on its status as a means of producing complete anosmia without confounding side effects.
Neuroprotective and cognitive enhancing effects of a multi-targeted food intervention in an animal model of neurodegeneration and depression
2014, NeuropharmacologyCitation Excerpt :Animals treated with ZnSO4 remained anosmic throughout the duration of the experiment, suggesting that one instillation of zinc sulfate is sufficient to damage the nasal epithelium, resulting in loss of olfactory function. These results are in accordance with previous reports (Alberts, 1974; Mar et al., 2000) Because animals treated with ZnSO4 remained anosmic throughout the duration of the experiment, histological verification was not necessary. Moreover, van Denderen et al. (2001) provided histological evidence that ZnSO4 infusion leads to damage of the olfactory fiber density and consequently anosmia.
Both olfactory epithelial and vomeronasal inputs are essential for activation of the medial amygdala and preoptic neurons of male rats
2011, NeuroscienceCitation Excerpt :These findings support our common belief that the OE receives volatile chemicals, while the VNO detects involatile chemicals. Because of the regeneration ability of OE sensory neurons, the effectiveness of anosmia induced by zinc sulfate lesion is limited in period (Alberts, 1974; Alberts and Galef, 1971; Thor and Flannelly, 1977). After the application of zinc sulfate, we first confirmed the anosmic effect within 2 days and tested for olfactory preference within a week.
Increased squalene concentrations in the clitoral gland during the estrous cycle in rats: An estrus-indicating scent mark?
2011, TheriogenologyCitation Excerpt :The VNO-ablation was carried out in the males as previously described [28]. Rats were anesthetized under light dose of diethyl ether and 5% ZnSO4 solution was administrated intranasally, to rupture the main olfactory epithelial cells [29]. Odor preferences of intact, VNO-ablated and ZnSO4–irrigated male rats were tested.
Accessory and main olfactory systems influences on predator odor-induced behavioral and endocrine stress responses in rats
2010, Behavioural Brain Research
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This paper was prepared during the author's tenure as a National Institute of Mental Health Predoctoral Fellow.
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I thank C. S. Sherrick for his critical readings and discussions, as well as J. E. Ahlskog, M. M. Clark, B. G. Galef, Jr., D. E. Klotzbach and P. K. Randall for their help.