Brief communicationAge-related sensitivity to kainate neurotoxicity
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Cited by (85)
Riluzole and novel naphthalenyl substituted aminothiazole derivatives prevent acute neural excitotoxic injury in a rat model of temporal lobe epilepsy
2023, NeuropharmacologyCitation Excerpt :The maturation of synaptic Glu neurotransmitter cycling after synaptic release to support continued excitatory transmission also develops during this period (Bolshakov and Siegelbaum, 1995; Wasling et al., 2004; Chowdhury et al., 2007; Hertz, 2013). SE induced neural excitotoxicity in the hippocampus and interconnected limbic regions by KA treatment also requires a mature hippocampal neural network that is similarly established and exists only after the third postnatal week (Nitecka et al., 1984; Wozniak et al., 1991; Haas et al., 2001). Activity regulated MeAIB/Gln transport activity develops during the second and third weeks in hippocampal neural cultures and is maximal after the third week (Erickson, 2017), as well.
Targeting the glutamatergic system to counteract organophosphate poisoning: A novel therapeutic strategy
2020, Neurobiology of DiseaseOpportunities for improving animal welfare in rodent models of epilepsy and seizures
2016, Journal of Neuroscience MethodsThe detrimental effect of aging on leptomeningeal collaterals in ischemic stroke
2014, Journal of Stroke and Cerebrovascular DiseasesCitation Excerpt :One aspect of aging that plays a role in this scenario is its detrimental effect on tissue outcome after an ischemic cerebral insult as shown both by experimental23,24 and human studies.12 Although an increase in the vulnerability of cerebral tissue to excitotoxicity25 or hypoxia26 because of aging might be the reason for such an observation, age-related changes in the cerebral vasculature could provide an alternative explanation. Aging causes a decrease in the number and diameter of leptomeningeal collaterals and increase in tortuosity of these vessels.9,10
The kainic acid model of temporal lobe epilepsy
2013, Neuroscience and Biobehavioral ReviewsMagnetic resonance imaging reveals that brain atrophy is more severe in older California sea lions with domoic acid toxicosis
2012, Harmful AlgaeCitation Excerpt :Wozniak et al. (1991) have shown that middle-aged rats (12–13 months) and old rats (22–25 months) are significantly more sensitive than young rats (5–6 months) to the neurotoxic actions of kainic acid (a DA mimic). Low doses of kainic acid, which were not toxic to young rats, triggered seizures, caused brain damage, and led to death in old rats (Wozniak et al., 1991). Middle-aged rats were more sensitive than young rats but less sensitive than old rats (Wozniak et al., 1991).
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Present address: Laboratory of Neurophysiology, NIH Animal Center, P.O. Box 289, Poolesville, MD 20837.