Neocortical synaptogenesis, aging, and behavior: Lifespan development in the motor-sensory system of the rat
References (39)
- et al.
Quantitative ultrastructural changes in rat cortical synapses during early-, mid- and late-adulthood
Brain Res.
(1982) - et al.
The formation of synaptic junctions in the developing rat brain: quantitative electron microscopic study
Brain Res.
(1967) - et al.
Postnatal development of locomotion in the laboratory rat
Anim. Behav.
(1975) - et al.
Effect of acute and chronic Centrophenoxine treatment on the synapses of cerebellar glomeruli in young rats
Mech. Ageing Dev.
(1984) - et al.
Postnatal development of synaptic contact zones in the visual cortex of rabbits
Brain Res.
(1978) - et al.
Synaptogenesis and changes in synaptic morphology related to acquisition of a new behavior
Brain Res.
(1985) - et al.
Quantitation of terminal parameters and their interrelationships in maturing central synapses: a perspective for experimental studies
Brain Res.
(1980) - et al.
Decrease in the number of synapses in the senescent brain: a quantitative electron microscopic analysis of the gentate gyrus molecular layer in the rat
Mech. Ageing Dev.
(1976) - et al.
Early postnatal development of the monkey visual system. II. Elimination of retinogeniculate synapses
Dev. Brain Res.
(1985) - et al.
Motor performance achievements in rats of different ages
Exp. Gerontol.
(1983)
Synaptic changes in the hypothalamic arcleus nucleus of old male rats
Exp. Neurol.
(1982)
The development of synapses in cerebral cortex of the human fetus
Brain Res.
(1973)
Effects of lead exposure during development on neocortical dendritic and synaptic structure
Exp. Neurol.
(1979)
Synaptic development in the human fetus: a morphometric analysis of normal and Down's syndrome neocortex
Exp. Neurol.
(1984)
Differential rearing effects on rat visual cortex synapses. 2. Synapse morphology
Dev. Brain Res.
(1985)
Age-related changes in the subiculum of Macaca mulatta: synaptic density
Exp. Neurol.
(1985)
Electron microscope study of development of cat superficial neocortex
Exp. Neurol.
(1963)
Changes in size and shape of synaptic connections after visual training: an ultrastructural approach of synaptic plasticity
Brain Res.
(1981)
The ontogenetic development of synaptic junctions. Synaptic activation and responsiveness to neurotransmitter substance in the rat cerebellar Purkinje cells
Brain Res.
(1971)
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This research was supported by a grant from the Natural Sciences and Engineering Research Council of Canada to T.L.P. The authors express their appreciation to Ms. Janelle LeBoutillier for her technical assistance.
Copyright © 1987 Published by Elsevier Inc.