GBR 12783, a potent and selective inhibitor of dopamine uptake: Biochemical studies in vivo and ex vivo
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Dopaminergic mechanisms underlying the expression of antipsychotic-induced dopamine supersensitivity in rats
2021, NeuropharmacologyCitation Excerpt :In Experiments 1–3, the different vehicles used produced similar locomotor responses and were pooled to form one vehicle control group. We assessed whether selectively blocking dopamine reuptake with GBR12783 (Bonnet and Costentin, 1986) [0, 5 or 10 mg/kg (Le Pen et al., 1996)] produces a supersensitive psychomotor response in haloperidol-treated rats. For comparison, we also assessed effects of the monoamine reuptake blocker cocaine (Rothman et al., 2001) [0, 2.5 or 10 mg/kg (Kosten, 1997)] and the D1/D2/monoamine receptor agonist apomorphine (Millan et al., 2002) [0, 0.25 or 0.5 mg/kg (Geyer et al., 1987; Barros et al., 1989)].
Involvement of dopamine D<inf>1</inf>/D<inf>2</inf> receptors on harmane-induced amnesia in the step-down passive avoidance test
2010, European Journal of PharmacologyThe role of N-glycosylation in function and surface trafficking of the human dopamine transporter
2004, Journal of Biological ChemistryCitation Excerpt :The cell line for DAT expression was the same, HEK-293, and there should be no difference between the stable transfection used here and the transient transfection applied by Torres et al. (11). We found dopamine uptake to be linear with time up to 2 min in wild type and up to 8 min in the mutants, and it is known that uptake kinetics are not exactly the same when measured in the linear phase (short time) or at plateau (longer time) (20). Torres et al. (11) measured uptake for 5 min.
Negative interaction of dopamine D2 receptor antagonists and GBR 12909 and GBR 12935 dopamine uptake inhibitors in the nucleus accumbens
2001, European Journal of PharmacologySynthesis of tropane and nortropane analogues with phenyl substitutions as serotonin transporter ligands
2001, Bioorganic and Medicinal ChemistryNovel monoamine transporter ligands reduce cocaine-induced enhancement of brain stimulation reward
2001, Pharmacology Biochemistry and Behavior