Elsevier

Brain Research

Volume 675, Issues 1–2, 27 March 1995, Pages 333-336
Brain Research

Short communication
Bicuculline blocks neuropeptide Y-induced phase advances when microinjected in the suprachiasmatic nucleus of syrian hamsters

https://doi.org/10.1016/0006-8993(95)00018-LGet rights and content

Abstract

Microinjection of neuropeptide Y (NPY) into the suprachiasmatic nucleus of the hypothalamus (SCN) during the middle of the subjective day (i.e. circadian time 6) causes large phase advances in circadian rhythms. The present study demonstrates that microinjection of the γ-aminobutyric acid (GABA) antagonist, bicuculline, completely blocks NPY-induced phase advances. These data indicate that GABAA activity within the SCN may mediate the phase shifting effects of some stimuli on the circadian pacemaker.

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