Research reportBlockade of mitral/tufted cell habituation to odors by association with reward: a preliminary note☆
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Cited by (30)
In vivo bioelectronic nose using transgenic mice for specific odor detection
2018, Biosensors and BioelectronicsCitation Excerpt :All of the odors were diluted in mineral oil to desired concentrations. During stimulation, odors were delivered to mouse snout for 5 s. Each odor was presented for consecutive trials with an intertrial interval of ≥ 1 min to reduce habituation (Wilson and Sullivan, 1992). Neural signals were analyzed off-line in MATLAB (The Mathworks Inc.).
Mechanisms underlying early odor preference learning in rats
2014, Progress in Brain ResearchCitation Excerpt :NE levels are lower to combined stimulation by 10 days of age (Rangel and Leon, 1995). NE in neonates also reduces MC habituation to repetitive odor presentations during associative training (Wilson and Sullivan, 1992). These early features of LC output support the ability of pups to efficiently make odor–UCS associations during the critical period (Moriceau and Sullivan, 2004).
Olfaction as a model system for the neurobiology of mammalian short-term habituation
2009, Neurobiology of Learning and MemoryMemory of early maltreatment: Neonatal behavioral and neural correlates of maternal maltreatment within the context of classical conditioning
2005, Biological PsychiatryCitation Excerpt :This the first study to examine changes in gene expression in the neonate brain following painful learning conditions, showing that a shock-induced odor preference is attributable to a decrease of Fos protein expression in the granule cell layer of the olfactory bulb, an increase of Fos expression in the anterior piriform cortex, and the lack of significant changes in the posterior piriform cortex and basolateral/lateral and central amygdaloid nuclei. We found learning-induced changes in the olfactory bulb, further confirming that the olfactory bulb encodes odor learning during early life (Johnson et al 1995; McLean et al 1999; Sullivan and Leon 1987; Sullivan and Wilson 1995; Wilson and Sullivan 1992; Wilson et al 1987; Woo and Leon 1987; Woo et al 1996; Yuan et al 2003, 2004). The olfactory bulb learning-associated changes are dependent on the reward causing the LC to release high levels of NE, which prevent mitral cell habituation to repeated odor presentations (Okutani et al 1998; Sullivan and Wilson 1994, 2003; Yuan et al 2003) and are only acquired during the early attachment period (Moriceau and Sullivan 2004b; Sullivan and Wilson 1995; Woo and Leon 1987).
Modality-specific impairments in response habituation following postnatal binge ethanol
2004, Neurotoxicology and TeratologyNeurobehavioral Development of Infant Learning and Memory: Implications for Infant Attachment
2004, Advances in the Study of BehaviorCitation Excerpt :Information about reward appears to reach the olfactory circuit via the LC directly into the olfactory bulb. As illustrated in Fig. 3, during acquisition the olfactory bulb primary output neurons (mitral cells) exhibit a heightened excitatory response in experimental pups (receive paired presentations of odor and reward) as compared with odor control groups (Wilson and Sullivan, 1992). Indeed, while mitral cells normally quickly habituate to repeated odor presentations, this habituation is prevented when that odor is paired with a reward.
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This research was supported by NSF Grant BNS88191891 to D.A.W. and NIH-NIDCD Grant DC00489 and NSF Grant BNS9110506 to R.M.S.