Elsevier

Brain Research

Volume 514, Issue 1, 23 April 1990, Pages 167-170
Brain Research

Granule cells in the ventral, but not dorsal, dentate gyrus are essential for kainic acid-induced wet dog shakes

https://doi.org/10.1016/0006-8993(90)90453-IGet rights and content

Abstract

Intrahippocampal injections of colchicine selectively destroy dentate granule cells. Wet dog shaking elicited by systemic administration of kainic acid is eliminated by bilateral destruction of ventral dentate granule cells but unaffected by bilateral destruction of dorsal dentate granule cells. This implies that ventral dentate granule cells are essential for the generationn of kainic acid-induced wet dog shakes.

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This research was supported in part by training Grant 5-T32-ES-07126 (L.M.G.).

1

We wish to thank Loretta Moore for manuscript preparation.

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