Mechanism of aminopyridine-induced ictal seizure activity in the cat neocortex
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Pharmacological evaluation of novel 1-[4-(4-benzo[1,3]dioxol-5-ylmethyl-piperazin-1-yl)-phenyl]-3-phenyl-urea as potent anticonvulsant and antidepressant agent
2016, Pharmacological ReportsCitation Excerpt :The results of 3-MPA and TSC induced seizures proposed that BPPU might activate GAD enzyme or inhibit GABA-T (aminotransferase) in the brain. 4-AP (K+ channel blocker) is a powerful convulsant in animals and humans [40] and this test is useful to differentiate the mode of action of anticonvulsant agents. It is believed that in 4-AP induced seizures, the epileptiform activity is facilitated by non-NMDA (N-methyl-d-aspartate) receptors.
Bistability of silence and seizure-like bursting
2013, Journal of Neuroscience MethodsCitation Excerpt :Low extracellular Ca2+ is associated with pathological oscillations and epilepsy (Pumain et al., 1985; Jefferys and Haas, 1982). The application of 4-AP is a common method for seizure initiation (Szente and Baranyi, 1998; Galvan et al., 1982; Yang et al., 2002; Takeshita and Bahar, 2011). For canonical parameter values, our new model describes this particular pharmacological scenario: treatment with Co2+ and 4-AP.
Repeated 4-aminopyridine induced seizures diminish the efficacy of glutamatergic transmission in the neocortex
2009, Experimental NeurologyGeneralization of seizures parallels the formation of "dark" neurons in the hippocampus and pontine reticular formation after focal-cortical application of 4-aminopyridine (4-AP) in the rat
2008, Brain ResearchCitation Excerpt :In the present study, we placed a small 4-aminopyridine (4-AP) crystal onto the exposed cortical surface. The 4-AP is a more selective potassium channel blocker than 3-AP and is known to cause electrographic seizures (Mihaly et al., 1990; Szente and Baranyi, 1987). To visualize the neurons injured by our 4-AP epileptic seizure model, we used a silver staining method that is a selective and sensitive marker of “dark” neurons (Gallyas et al., 1990) and, in contrast to the traditional silver staining methods, gives reproducible results (Newman and Jasani, 1998).