Elsevier

Brain Research

Volume 260, Issue 2, 7 February 1983, Pages 326-329
Brain Research

Effects of lesions in the paraventricular nucleus of the hypothalamus on vasopressin and oxytocin contents in brainstem and spinal cord of rat

https://doi.org/10.1016/0006-8993(83)90690-XGet rights and content

Abstract

The effects of lesions of the paraventricular nucleus in rat hypothalamis (PVN) on the vasopressin (AVP) and oxytocin (OT) contents of the brainstem and spinal cord, as measured by radioimmunoassay, were studied. AVP decreased by 50% and 80% in brainstem and spinal cord of lesioned animals, whereas OT disappeared almost completely. Therefore, in contrast to OT, the PVN is not the only site of origin of AVP-containing nerve fibers projecting to the brainstem.

References (12)

There are more references available in the full text version of this article.

Cited by (114)

  • Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits

    2022, Neuroscience and Biobehavioral Reviews
    Citation Excerpt :

    This finding was substantiated by a different study utilizing male rats, which found that complete ablation of the PVN led to a more than 90% reduction in OXT peptide concentration within the brainstem and spinal cord. Complete ablation of the PVN also impacted AVP peptide concentration, which was reduced by 50% in the brainstem and by more than 80% in the spinal cord (Lang et al., 1983). This evidence confirms that damage to the HPIT region disrupts both OXT and AVP production; therefore, it is reasonable to propose that HPIT damage caused by CP, CNS LCH, or IGCTs could similarly lead to disruptions in OXT and/or AVP signaling.

  • Activation of V<inf>1a</inf> vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels

    2021, Neuropharmacology
    Citation Excerpt :

    After synthesis in the hypothalamus, these hormones are transported along the axons of these neurosecretory cells to the posterior pituitary where they are released into the blood stream to play their traditional physiological functions on blood vessels, kidney and uterus (Stoop, 2012). In addition to these neurosecretory functions, AVP and oxytocin also travel along the axonal projections from parvocellular neurons of the hypothalamus to discrete extrahypothalamic limbic brain regions including the hippocampus, subiculum, amygdala and nucleus accumbens (Buijs, 1978; Buijs and Swaab, 1979; DeVries et al., 1985; Hawthorn et al., 1985; Lang et al., 1983). Whereas the hypothalamus is the major source of AVP and oxytocin in the brain, AVP immunoreactivity has also been detected in neurons in the extrahypothalamic structures including the bed nucleus of stria terminalis, septal region, medial amygdala and locus coeruleus (Caffe and van Leeuwen, 1983; Sofroniew, 1985; van Leeuwen and Caffe, 1983) (for a review see (Cilz et al., 2019)).

  • Headache: Endocrinological aspects

    2010, Handbook of Clinical Neurology
View all citing articles on Scopus
View full text