Effects of lesions in the paraventricular nucleus of the hypothalamus on vasopressin and oxytocin contents in brainstem and spinal cord of rat
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Socio-behavioral dysfunction in disorders of hypothalamic-pituitary involvement: The potential role of disease-induced oxytocin and vasopressin signaling deficits
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :This finding was substantiated by a different study utilizing male rats, which found that complete ablation of the PVN led to a more than 90% reduction in OXT peptide concentration within the brainstem and spinal cord. Complete ablation of the PVN also impacted AVP peptide concentration, which was reduced by 50% in the brainstem and by more than 80% in the spinal cord (Lang et al., 1983). This evidence confirms that damage to the HPIT region disrupts both OXT and AVP production; therefore, it is reasonable to propose that HPIT damage caused by CP, CNS LCH, or IGCTs could similarly lead to disruptions in OXT and/or AVP signaling.
Activation of V<inf>1a</inf> vasopressin receptors excite subicular pyramidal neurons by activating TRPV1 and depressing GIRK channels
2021, NeuropharmacologyCitation Excerpt :After synthesis in the hypothalamus, these hormones are transported along the axons of these neurosecretory cells to the posterior pituitary where they are released into the blood stream to play their traditional physiological functions on blood vessels, kidney and uterus (Stoop, 2012). In addition to these neurosecretory functions, AVP and oxytocin also travel along the axonal projections from parvocellular neurons of the hypothalamus to discrete extrahypothalamic limbic brain regions including the hippocampus, subiculum, amygdala and nucleus accumbens (Buijs, 1978; Buijs and Swaab, 1979; DeVries et al., 1985; Hawthorn et al., 1985; Lang et al., 1983). Whereas the hypothalamus is the major source of AVP and oxytocin in the brain, AVP immunoreactivity has also been detected in neurons in the extrahypothalamic structures including the bed nucleus of stria terminalis, septal region, medial amygdala and locus coeruleus (Caffe and van Leeuwen, 1983; Sofroniew, 1985; van Leeuwen and Caffe, 1983) (for a review see (Cilz et al., 2019)).
History of hypothalamic research: “The spring of primitive existence”
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