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2017, NeuroscienceCitation Excerpt :Recent efforts toward understanding these processes have established operant methods to measure pain-related behaviors in rodents (e.g., King et al., 2009), with the hope of providing additional construct and translational validity with regard to the interaction of pain and motivational (or goal-directed) behavior. At the neurobiological level, mu-opioid receptors in the ventral striatum (Olds, 1982), ventral tegmental area (Phillips and LePiane, 1980), and hippocampus (Stevens et al., 1991) mediate the acute rewarding effects of opioids. The ventral striatum is a brain region associated with reward, reinforcement learning, and motivation, which along with regions including the hippocampus and prefrontal cortex, has been implicated in the progression from initial drug use to addiction (Edwards and Koob, 2010).
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2017, Neuroscience and Biobehavioral ReviewsCitation Excerpt :However, further studies showed that mesolimbic DA terminals or DA receptors in nucleus accumbens (NAcc) are not necessary for either heroin self-administration (Ettenberg et al., 1982; Pettit et al., 1984) or locomotion induced by intra-NAcc infusions of an enkephalin analog (Kalivas et al., 1983; Vaccarino et al., 1986). In addition, morphine infusions into the NAcc, where high densities of opioid receptor subtypes are expressed (Erbs et al., 2015; Kitchen et al., 1997; Mansour et al., 1987) − downstream from dopaminergic synapses − support self-administration in rats and mice (Olds, 1982; David and Cazala 2000). Injections of the opioid antagonist methylnaloxonium into the NAcc, for example, have been shown to block locomotion induced by systemic heroin in rats (Amalric and Koob, 1985).