Inhibition of spinal cord interneurons by narcotic microinjection and focal electrical stimulation in the periaqueductal gray matter
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Cited by (130)
Spinal and supraspinal N-methyl-d-aspartate and melanocortin-1 receptors contribute to a qualitative sex difference in morphine-induced hyperalgesia
2015, Physiology and BehaviorCitation Excerpt :This finding indicates that, in addition to a distinct hyperalgesia system mediated by MC1Rs, female mice possess a male typical NMDAR hyperalgesic mechanism which is precluded from use by ovarian sex steroids. It is well documented that morphine modulation of nociception is regulated by multiple sites, notably including spinal loci such as superficial layers of the dorsal horn, dorsal root ganglia [15,16], and supraspinal loci such as the periaqueductal gray (PAG), and the rostroventral medulla (RVM) [15,17–22]. Furthermore, previous studies have also suggested that a multitude of these areas involved in morphine antinociception are also implicated in MIH.
C-Fos activation in the periaqueductal gray following acute morphine-3β-d-glucuronide or morphine administration
2014, Physiology and BehaviorCitation Excerpt :However, the present study is the first to investigate the role of the midbrain PAG in M3G-induced hyperalgesia in mice. Given the critical role of the PAG in modulating pain processing [4,6,22,23,26] and the ability of systemic M3G to activate PAG neurons (the current studies), it is quite possible that M3G, at least in part, causes hyperalgesia by activating PAG neurons. The present finding is not likely attributable to the non-specific effects of subject handling, injection protocols, or NTX per se since there were no significant differences between these control groups.
Spinal and Supraspinal Mechanisms of Placebo Analgesia
2013, Placebo and Pain: From Bench to BedsideInvolvement of the periaqueductal gray in the effect of motor cortexstimulation
2013, Brain ResearchCitation Excerpt :It was reported that morphine and other opioids inhibit local GABAergic neurons in the PAG and reduce the release of GABA within the PAG which activates PAG output neurons and the descending inhibitory pathway (Ingram et al., 1998; Vaughan et al., 1997). A morphine microinjection into the PAG also reduced the response of projection neurons in the dorsal horn to peripheral nociceptive stimuli (Bennett and Mayer, 1979). Two previous studies demonstrated the involvement of endogenous opioids in the effect of MCS.
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Present address: National Institute of Dental Research, NIH, Building 30, B2 Bethesda, Md. 20014 (U.S.A.)
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