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Cited by (282)
5.38 - Peripheral Mechanisms of Neuropathic Pain Following Nerve Injury
2020, The Senses: A Comprehensive Reference: Volume 1-7, Second EditionHistopathological Characterization of Tail Injury and Traumatic Neuroma Development after Tail Docking in Piglets
2016, Journal of Comparative PathologyCitation Excerpt :It has been suggested that neuroma formation following tail docking may cause detrimental sensory changes in the tail due to altered peripheral nerve activity that may cause pain or chronic discomfort (Simonsen et al., 1991). Following peripheral nerve injury, it has long been recognized that regenerating endings of afferent sensory fibres can become trapped within scar tissue and produce spontaneous or abnormal neuronal firing (Govrin-Lippmann and Devor, 1978; Devor, 1983). This may lead to changes in peripheral sensitivity to mechanical and thermal stimulation, manifesting as altered sensations that range from anaesthesia, paraesthesia, dysaesthesia (unpleasant abnormal sensation) to pain (Holland and Robinson, 1998; Rajput et al., 2012).
Contribution of hyperpolarization-activated channels to heat hypersensitivity and ongoing activity in the neuritis model
2015, NeuroscienceCitation Excerpt :Spinal mechanisms that lead to mechanical and heat hypersensitivities are reputed to be driven by aberrant peripheral activity from primary sensory neurons, for example, ongoing (spontaneous) activity (LaMotte et al., 1991; Gracely et al., 1992; Xie et al., 2005; Campbell and Meyer, 2006; Staud, 2011; Woolf, 2011). Such activity is typically associated with a nerve injury, whether it develops at the cut tips of axotomized axons (Govrin-Lippmann and Devor, 1978; Michaelis et al., 1995; Tal and Eliav, 1996) or from apparently uninjured neurons (Djouhri et al., 2012). However, for many patients who present with the symptoms of neuropathic pain, signs of a nerve injury are absent on routine clinical examination.
Supported by grants from the Fritz Thyssen Stiftung and the Israel Center for Psychobiology.
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We thank W. H. Calvin, Z. Seltzer and P. D. Wall for their advice.