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Depressed by Learning—Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells

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Abstract

Climbing fiber-driven long-term depression (LTD) of parallel fiber synapses onto cerebellar Purkinje cells has long been investigated as a putative mechanism of motor learning. We recently discovered that the rules governing the induction of LTD at these synapses vary across different regions of the cerebellum. Here, we discuss the design of LTD induction protocols in light of this heterogeneity in plasticity rules. The analytical advantages of the cerebellum provide an opportunity to develop a deeper understanding of how the specific plasticity rules at synapses support the implementation of learning.

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Acknowledgements

We are grateful for Jaydev Bhateja for his comments and suggestions.

Funding

AS was supported by the Research Institute of the McGill University Health Centre and McGill University as well as by funding from the Canada First Research Excellence Fund, awarded to McGill University for the Healthy Brains for Healthy Lives initiative. JR was supported by NIH R01NS072406, R01DC004154 and the Simons Foundation Collaboration on the Global Brain no. 54031.

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Authors and Affiliations

  1. Centre for Research in Neuroscience, Department of Neurology and Neurosurgery, Department of Pediatrics, Brain Repair and Integrative Neuroscience Program, the Research Institute of the McGill University Health Centre, McGill University, Montréal General Hospital, Montréal, Quebec, H3G 1A4, Canada

    Aparna Suvrathan

  2. Department of Neurobiology, Stanford University, Stanford, CA, 94305, USA

    Jennifer L. Raymond

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  1. Aparna Suvrathan
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  2. Jennifer L. Raymond
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Correspondence to Jennifer L. Raymond.

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Suvrathan, A., Raymond, J.L. Depressed by Learning—Heterogeneity of the Plasticity Rules at Parallel Fiber Synapses onto Purkinje Cells. Cerebellum 17, 747–755 (2018). https://doi.org/10.1007/s12311-018-0968-8

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