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Intrinsic Connectivity Networks Within Cerebellum and Beyond in Eating Disorders

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Abstract

Cerebellum seems to have a role both in feeding behavior and emotion regulation; therefore, it is a region that warrants further neuroimaging studies in eating disorders, severe conditions that determine a significant impairment in the physical and psychological domain. The aim of this study was to examine the cerebellum intrinsic connectivity during functional magnetic resonance imaging resting state in anorexia nervosa (AN), bulimia nervosa (BN), and healthy controls (CN). Resting state brain activity was decomposed into intrinsic connectivity networks (ICNs) using group spatial independent component analysis on the resting blood oxygenation level dependent time courses of 12 AN, 12 BN, and 10 CN. We extracted the cerebellar ICN and compared it between groups. Intrinsic connectivity within the cerebellar network showed some common alterations in eating disordered compared to healthy subjects (e.g., a greater connectivity with insulae, vermis, and paravermis and a lesser connectivity with parietal lobe); AN and BN patients were characterized by some peculiar alterations in connectivity patterns (e.g., greater connectivity with the insulae in AN compared to BN, greater connectivity with anterior cingulate cortex in BN compared to AN). Our data are consistent with the presence of different alterations in the cerebellar network in AN and BN patients that could be related to psychopathologic dimensions of eating disorders.

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Acknowledgment

The present paper is a publication sponsored by the “Compagnia di San Paolo” Bank Foundation with the Grant “Bando Neuroscienze” (code 3929IT/PF 2008.2242) assigned in 2009 to Prof. Secondo Fassino and Dr. Federico Amianto.

Conflict of Interest

The authors declare that potential conflicts of interest do not exist.

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Authors and Affiliations

  1. Department of Neuroscience, AOU San Giovanni Battista, Via Cherasco, 15, 10126, Turin, Italy

    F. Amianto, F. D’Agata, L. Lavagnino, P. Caroppo, G. Abbate-Daga, M. Bergui, P. Mortara & S. Fassino

  2. Department of Radiology, AOU San Giovanni Battista, C.so Dogliotti, Turin, Italy

    D. Righi

  3. Department of Psychiatry, AO San Paolo, Via di Rudinì, Milan, Italy

    S. Scarone

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  1. F. Amianto
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Correspondence to F. D’Agata.

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D’Agata and Amianto equally contributed to this work.

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Amianto, F., D’Agata, F., Lavagnino, L. et al. Intrinsic Connectivity Networks Within Cerebellum and Beyond in Eating Disorders. Cerebellum 12, 623–631 (2013). https://doi.org/10.1007/s12311-013-0471-1

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