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Effects of ovarian dopaminergic receptors on ovulation

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Abstract

Hormonal and neural signals regulate the ovarian follicular development. The present study’s hypothesis is that the blockade of ovarian dopamine receptors locally will affect follicle development and ovulation. Groups of adult 4-day cyclic rats of the CII-ZV strain on estrus, diestrus-1, diestrus-2, or proestrus day were injected with vehicle, haloperidol (DA2 > DA1 blocker), sulpiride (DA2 blocker), or SCH-23390 (DA1 blocker) into the bursa of both ovaries at 08:00, 13:00, or 20:00 h. Animals were sacrificed the following predicted estrus day. The following treatments blocked ovulation: injecting haloperidol to rats on estrus or diestrus-1 at 8:00, 13:00, or 20:00 h and to rats on diestrus-2 at 08:00, or 20:00 h; injecting SCH-23390 to rats on diestrus-1 at 8:00, 13:00, or 20:00 h; injecting sulpiride to rats on estrus at 20:00 h, diestrus-1 at 08:00, 13:00, or 20:00 h and to rats on diestrus-2 at 08:00 h. In rats treated with any of the dopamine antagonists that blocked ovulation, injecting GnRH at 14.00 h on the next predicted proestrus day restored ovulation. Injecting estradiol benzoate at 14.00 h of the next predicted diestrus-2 restored ovulation in some animals treated with haloperidol on estrus or diestrus-2 and was ineffective in rats treated on diestrus-1. In rats treated with sulpiride or SCH-23390 ovulation occurred in most animals (SCH-23390: 6/8; SPD: 9/12). Present results suggest that dopamine ovarian receptors’ participation in regulating follicular development and ovulation varies along the estrus cycle, with their most prominent activity occurring on diestrus-1.

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Acknowledgments

This work was supported by CONACYT Grant 316181 to B. Venegas. We thank MSc Alvaro Domínguez-González for the assistance in the English revision.

Conflict of interest

The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research.

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Authors and Affiliations

  1. Departamento de Biología y Toxicología de la Reproducción, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, CP.72570, Puebla, Mexico

    Berenice Venegas-Meneses, José Francisco Padilla, Claudia Elvira Juárez, José Luis Morán, Carolina Morán & Anabella Handal

  2. Laboratorio de Bioquímica y Biología Molecular, Instituto de Ciencias, Benemérita Universidad Autónoma de Puebla, Puebla, Mexico

    Nora Hilda Rosas-Murrieta

  3. Biology of Reproduction Research Unit, Facultad de Estudios Superiores Zaragoza, UNAM, Mexico, D.F., Mexico

    Roberto Domínguez

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  1. Berenice Venegas-Meneses
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Venegas-Meneses, B., Padilla, J.F., Juárez, C.E. et al. Effects of ovarian dopaminergic receptors on ovulation. Endocrine 50, 783–796 (2015). https://doi.org/10.1007/s12020-015-0636-4

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