Abstract
In modern biomedicine, the increasing need to develop experimental models to further our understanding of disease conditions and delineate innovative treatments has found in the zebrafish (Danio rerio) an experimental model, and indeed a valuable asset, to close the gap between in vitro and in vivo assays. Translation of ideas at a faster pace is vital in the field of neurodegeneration, with the attempt to slow or prevent the dramatic impact on the society’s welfare being an essential priority. Our research group has pioneered the use of zebrafish to contribute to the quest for faster and improved understanding and treatment of neurodegeneration in concert with, and inspired by, many others who have primed the study of the zebrafish to understand and search for a cure for disorders of the nervous system. Aware of the many advantages this vertebrate model holds, here, we present an update on the recent zebrafish models available to study neurodegeneration with the goal of stimulating further interest and increasing the number of diseases and applications for which they can be exploited. We shall do so by citing and commenting on recent breakthroughs made possible via zebrafish, highlighting their benefits for the testing of therapeutics and dissecting of disease mechanisms.
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Acknowledgments
Thank you to all members of the Claire Russell and Michelangelo Campanella’s research group for the on-going support. RMJ is a postdoctoral researcher funded by a research grant to CR and MC from SPARKS children’s charity.
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Rebeca Martín-Jiménez, Michelangelo Campanella and Claire Russell declare that they have no conflict of interest.
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This article does not contain any studies with human or animal subjects performed by any of the authors.
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Martín-Jiménez, R., Campanella, M. & Russell, C. New Zebrafish Models of Neurodegeneration. Curr Neurol Neurosci Rep 15, 33 (2015). https://doi.org/10.1007/s11910-015-0555-z
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DOI: https://doi.org/10.1007/s11910-015-0555-z