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Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study

  • Neurology and Preclinical Neurological Studies - Short communication
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Abstract

We evaluated the effects of transcranial random noise stimulation (tRNS) on fatigue in 17 subjects with relapsing–remitting multiple sclerosis with low physical disability. Two different patient groups underwent real or sham stimulation for 10 days, targeting the primary motor cortex of the dominant side or contralateral to the most compromised limb. In the ‘real group’, beneficial effects were observed using the Modified Fatigue Impact Scale (p = 0.04; physical subscale: p = 0.03), the subscales ‘change in health’ (p = 0.006) and ‘role limitations due to physical problems’ (p = 0.001) of the Multiple Sclerosis Quality of Life-54, and by assessing the patient impression of perceived fatigue (p = 0.005).

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Acknowledgements

We thank all the patients who participated in the study.

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Correspondence to Paolo Ragonese.

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The authors declare to have no conflict of interest.

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The Ethical Committee of the Medical University of Palermo approved this study. It was performed in accordance with the ethical standards as laid down in the 1964 Declaration of Helsinki and its later amendments. Written informed consent was obtained from all participants.

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Salemi, G., Vazzoler, G., Ragonese, P. et al. Application of tRNS to improve multiple sclerosis fatigue: a pilot, single-blind, sham-controlled study. J Neural Transm 126, 795–799 (2019). https://doi.org/10.1007/s00702-019-02006-y

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  • DOI: https://doi.org/10.1007/s00702-019-02006-y

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