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A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat

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Abstract

The lateral hypothalamic area (LHA) has two major roles: arousal/waking and food intake controls. Here, it is shown that a premammillary part of the LHA is neurochemically and cytoarchitectonically distinct from the tuberal LHA in male rats. This part contains nuclear masses, namely the parasubthalamic nucleus and the calbindin nucleus, involved in pathways that predict its participation in the control of food intake. Analyzing c-Fos expression in experiments related to feeding behavior, this region responded specifically to the ingestion of palatable nutriments.

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Abbreviations

AAA:

Anterior amygdalar area

Ac:

Anterior commissure

ACB:

Nucleus accumbens

Aco:

Anterior commissure, olfactory limb

ADP:

Anterodorsal preoptic nucleus

AHN:

Anterior hypothalamic nucleus

AId:

Agranular insular area, dorsal part

AIp:

Agranular insular area, posterior part

AIv:

Agranular insular area, ventral part

AMB:

Nucleus ambiguus

AMBd:

Nucleus ambiguus, dorsal division

AMY:

Amygdala

AP:

Area postrema

AQ:

Cerebral aqueduct proper (sylvius)

ARH:

Arcuate hypothalamic nucleus

AVP:

Anteroventral preoptic nucleus

B:

Barrington’s nucleus

BLA:

Basolateral amygdalar nucleus

BMA:

Basomedial amygdalar nucleus

BMAa:

Basomedial amygdalar nucleus, anterior part

BMAp:

Basomedial amygdalar nucleus, posterior part

BST:

Bed nuclei stria terminalis

cb:

Calbindin

cbN:

Calbindin nucleus

cc:

Corpus callosum

ccg:

Corpus callosum, genu

CEA:

Central amygdalar nucleus

CEAc:

Central amygdalar nucleus, capsular part

CEAm:

Central amygdalar nucleus, medial part

CGRP:

Calcitonin gene-related peptide

CLA:

Claustrum

CLI:

Central linear nucleus raphe

COAa:

Cortical amygdalar nucleus, anterior part

CP:

Caudoputamen

cpd:

Cerebral peduncle

CS:

Superior central nucleus raphe

CU:

Cuneate nucleus

CUN:

Cuneiform nucleus

dend.:

Dendrite

DMH:

Dorsomedial hypothalamic nucleus

DMX:

Dorsal motor nucleus vagus nerve

DR:

Dorsal nucleus raphe

DTN:

Dorsal tegmental nucleus

EPd:

Endopiriform nucleus, dorsal part

EW:

Edinger–Westphal nucleus

FF:

Fields of Forel

FG:

Fluorogold

fr:

Fasciculus retroflexus

FS:

Striatal fundus

Fx:

Columns of the fornix

GABA:

Gamma-aminobutyric acid

GAD:

Glutamic acid decarboxylase

GP:

Globus pallidus

GR:

Gracile nucleus, principal part

GRN:

Gigantocellular reticular nucleus

GU:

Gustatory area

Hcrt:

Hypocretin

ic:

Internal capsule

IC:

Inferior colliculus

ICc:

Inferior colliculus, central nucleus

IF:

Interfascicular nucleus raphe

IG:

Induseum griseum

III:

Oculomotor nucleus

INC:

Interstitial nucleus of cajal

INS:

Insular region

IO:

Inferior olivary complex

IPN:

Interpeduncular nucleus

KF:

Kölliker–Fuse subnucleus (of PB)

LA:

Lateral amygdalar nucleus

Lat:

Lateral part of the LHA

LC:

Locus ceruleus

LDT:

Laterodorsal tegmental nucleus

LGN:

Lateral geniculate nucleus

LH:

Lateral habenula

LHA:

Lateral hypothalamic area

LHApm:

Lateral hypothalamic area, premammillary region

LHAt:

Lateral hypothalamic area, tuberal region

LM:

Lateral mammillary nucleus

LPO:

Lateral preoptic area

LRNm:

Lateral reticular nucleus, magnocellular part

LSc:

Lateral septal nucleus, caudal (caudodorsal) part

LSr:

Lateral septal nucleus, rostral (rostroventral) part

LSv:

Lateral septal nucleus, ventral part

MA:

Magnocellular nucleus

MARN:

Magnocellular reticular nucleus

MCH:

Melanin-concentrating hormone

MDRN:

Medullary reticular nucleus

ME:

Median eminence

MEA:

Medial amygdalar nucleus

MH:

Medial habenula

MM:

Medial mammillary nucleus, body

MPN:

Medial preoptic nucleus

MPO:

Medial preoptic area

MRNm:

Midbrain reticular nucleus, magnocellular part

MS:

Medial septal nucleus

mtt:

Mammillothalamic tract

MV:

Medial vestibular nucleus

NADPH:

Nicotinamide adenine dinucleotide phosphate

ND:

Nucleus of Darkschewitsch

NDB:

Diagonal band nucleus

NG:

Nucleus gemini

NLOT:

Nucleus of the lateral olfactory tract

NPC:

Nucleus of the posterior commissure

NR:

Nucleus of Roller

NTB:

Nucleus of the trapezoid body

NTS:

Nucleus of the solitary tract

och:

Optic chiasm

opt:

Optic tract

OT:

Olfactory tubercle

PAG:

Periaqueductal gray

PARN:

Parvicellular reticular nucleus

PB:

Parabrachial nucleus

PBl:

Parabrachial nucleus, lateral division

PBm:

Parabrachial nucleus, medial division

PCG:

Pontine central gray

PF:

Perifornical region of the LHA

PG:

Pontine gray

PGRNl:

Paragigantocellular reticular nucleus, lateral part

PH:

Posterior hypothalamic nucleus

PHA-L:

Phaseolus vulgaris leucoagglutinin

PIR:

Piriform area

pm:

Principal mammillary tract

PMd:

Dorsal premammillary nucleus

PMv:

Ventral premammillary nucleus

POR:

Periolivary region

PPN:

Pedunculopontine nucleus

PRC:

Precommissural nucleus, periaqueductal gray

PRNc:

Pontine reticular nucleus, caudal part

PRNr:

Pontine reticular nucleus, rostral part

PS:

Parastrial nucleus

PSTN:

Parasubthalamic nucleus

PSV:

Principal sensory nucleus of the trigeminal

pTK1:

Preprotachykinin 1

PV:

Parvalbumin

PV1:

Parvalbumin nucleus

PVH:

Paraventricular hypothalamic nucleus

PVHdp:

Paraventricular hypothalamic nucleus, dorsal parvicellular part

PVHmpv:

Paraventricular hypothalamic nucleus, medial parvicellular part, ventral zone

PVHpml:

Paraventricular hypothalamic nucleus, posterior magnocellular part, lateral zone

PVp:

Periventricular hypothalamic nucleus, posterior part

PVT:

Paraventricular thalamic nucleus

RE:

Nucleus reuniens

RL:

Rostral linear nucleus raphe

RM:

Nucleus raphe magnus

RN:

Red nucleus

SC:

Superior colliculus

SCH:

Suprachiasmatic nucleus

SCi:

Superior colliculus, intermediate layer

SF:

Septofimbrial nucleus

SH:

Septohippocampal nucleus

SI:

Substantia innominata

SLD:

Sublaterodorsal nucleus

sm:

Stria medullaris

SNc:

Substantia nigra, compact part

SNr:

Substantia nigra, reticular part

SON:

Supraoptic nucleus

SP:

Substance P

SPVC:

Spinal nucleus of the trigeminal, caudal part

SPVI:

Spinal nucleus of the trigeminal, interpolar part

STN:

Subthalamic nucleus

SUM:

Supramammillary nucleus

TH:

Tyrosine hydroxylase

TMd:

Tuberomammillary nucleus, dorsal part

TMv:

Tuberomammillary nucleus, ventral part

TRN:

Tegmental reticular nucleus, pontine gray

TTd2:

Tenia tecta, dorsal part, layers 2

TU:

Tuberal nucleus

TUte:

Tuberal nucleus, terete subnucleus

V3:

Third ventricle

V3m:

Third ventricle, mammillary recess

V4:

Fourth ventricle proper

VIS:

Visual area

vlt:

Ventrolateral hypothalamic tract

Vma:

Motor nucleus of the trigeminal, magnocellular part

VMH:

Ventromedial hypothalamic nucleus

VPMpc:

Ventral posteromedial nucleus thalamus, parvicellular part

VTA:

Ventral tegmental area

VTN:

Ventral tegmental nucleus

XII:

Hypoglossal nucleus

ZI:

Zona incerta

ZIda:

Zona incerta, dopaminergic group

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Acknowledgments

This work was supported by funding from the French Ministère de la Recherche et de la Technologie (EA 3922) and from the Région de Franche-Comté. The authors thank C. Houdayer, G. Franchi-Bernard, F. Poncet and A. Mariot for technical assistances. We thank G. Sanchez-Watts, D. M. Simmons, R. H. Thompson, G. D. Petrovich, E. A. Markakis, A. B. Kelly and L. W. Swanson for helping to prepare the in situ hybridization material and A. Tobin for the GAD65 and GAD67 probes.

Conflict of interest

The authors declare that they have no conflict of interest.

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Correspondence to Pierre-Yves Risold.

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Chometton, S., Pedron, S., Peterschmitt, Y. et al. A premammillary lateral hypothalamic nuclear complex responds to hedonic but not aversive tastes in the male rat. Brain Struct Funct 221, 2183–2208 (2016). https://doi.org/10.1007/s00429-015-1038-3

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  • DOI: https://doi.org/10.1007/s00429-015-1038-3

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