Abstract
Experimental studies suggest that increased resting-state power of gamma oscillations is associated with autism spectrum disorder (ASD). To extend the clinical applicability of this finding, we retrospectively investigated routine electroencephalography (EEG) recordings of 19 patients with ASD and 19 age- and gender-matched controls. Relative resting-state condition gamma spectral power was variable, but on average significantly increased in children with ASD. This effect remained when excluding electrodes associated with myogenic gamma activity. These findings further indicate that increased resting-state gamma activity characterizes a subset of ASD and may also be detected by routine EEG as a clinically accessible and well-tolerated investigation.
References
Rubenstein JL, Merzenich MM (2003) Model of autism: increased ratio of excitation/inhibition in key neural systems. Genes Brain Behav 2(5):255–267
Wang J, Barstein J, Ethridge LE, Mosconi MW, Takarae Y, Sweeney JA (2013) Resting state EEG abnormalities in autism spectrum disorders. J Neurodev Disord 5(1):24. doi:10.1186/1866-1955-5-24
Gatto CL, Broadie K (2010) Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models. Front Synaptic Neurosci 2:4. doi:10.3389/fnsyn.2010.00004
Markram K, Markram H (2010) The intense world theory—a unifying theory of the neurobiology of autism. Front Hum Neurosci 4:224. doi:10.3389/fnhum.2010.00224
Orekhova EV, Stroganova TA, Nygren G, Tsetlin MM, Posikera IN, Gillberg C, Elam M (2007) Excess of high frequency electroencephalogram oscillations in boys with autism. Biol Psychiatry 62(9):1022–1029. doi:10.1016/j.biopsych.2006.12.029
Maxwell CR, Villalobos ME, Schultz RT, Herpertz-Dahlmann B, Konrad K, Kohls G (2013) Atypical laterality of resting gamma oscillations in autism spectrum disorders. J Autism Dev Disord. doi:10.1007/s10803-013-1842-7
Cornew L, Roberts TP, Blaskey L, Edgar JC (2012) Resting-state oscillatory activity in autism spectrum disorders. J Autism Dev Disord 42(9):1884–1894. doi:10.1007/s10803-011-1431-6
Gross J, Baillet S, Barnes GR, Henson RN, Hillebrand A, Jensen O, Jerbi K, Litvak V, Maess B, Oostenveld R, Parkkonen L, Taylor JR, van Wassenhove V, Wibral M, Schoffelen JM (2013) Good practice for conducting and reporting MEG research. Neuroimage 65:349–363. doi:10.1016/j.neuroimage.2012.10.001
Buzsaki G, Draguhn A (2004) Neuronal oscillations in cortical networks. Science 304(5679):1926–1929. doi:10.1126/science.1099745
Uhlhaas PJ, Singer W (2006) Neural synchrony in brain disorders: relevance for cognitive dysfunctions and pathophysiology. Neuron 52(1):155–168. doi:10.1016/j.neuron.2006.09.020
Whitham EM, Pope KJ, Fitzgibbon SP, Lewis T, Clark CR, Loveless S, Broberg M, Wallace A, DeLosAngeles D, Lillie P, Hardy A, Fronsko R, Pulbrook A, Willoughby JO (2007) Scalp electrical recording during paralysis: quantitative evidence that EEG frequencies above 20 Hz are contaminated by EMG. Clin Neurophysiol 118(8):1877–1888. doi:10.1016/j.clinph.2007.04.027
Grice SJ, Spratling MW, Karmiloff-Smith A, Halit H, Csibra G, de Haan M, Johnson MH (2001) Disordered visual processing and oscillatory brain activity in autism and Williams syndrome. NeuroReport 12(12):2697–2700
Wilson TW, Rojas DC, Reite ML, Teale PD, Rogers SJ (2007) Children and adolescents with autism exhibit reduced MEG steady-state gamma responses. Biol Psychiatry 62(3):192–197. doi:10.1016/j.biopsych.2006.07.002
Geiger A, Huber R, Kurth S, Ringli M, Jenni OG, Achermann P (2011) The sleep EEG as a marker of intellectual ability in school age children. Sleep 34(2):181–189
Bewernitz M, Derendorf H (2012) Electroencephalogram-based pharmacodynamic measures: a review. Int J Clin Pharmacol Ther 50(3):162–184
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van Diessen, E., Senders, J., Jansen, F.E. et al. Increased power of resting-state gamma oscillations in autism spectrum disorder detected by routine electroencephalography. Eur Arch Psychiatry Clin Neurosci 265, 537–540 (2015). https://doi.org/10.1007/s00406-014-0527-3
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DOI: https://doi.org/10.1007/s00406-014-0527-3