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Basal ganglia network mediates the control of movement amplitude

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Abstract

In the present study we address the hypothesis that the basal ganglia are specifically involved in the planning of movement amplitude (or related covariates). This prediction has often been put forward based on the observation that Parkinson's disease (PD) patients exhibit hypokinesia. A close examination of the literature shows, however, that this commonly reported clinical symptom is not consistently echoed by experimental observations. When required to point to visual targets in the absence of vision of the moving limb, PD subjects exhibit various patterns of inaccuracy, including hypometria, hypermetria, systematic direction bias, or direction-dependent errors. They have even been shown to be as accurate as healthy, age-matched subjects. The main aim of the current study is to address the origin of these inconsistencies. To this end, we required nine patients presenting with advanced PD and 15 age-matched control subjects to perform planar reaching movements to visual targets. Eight targets were presented in equally spaced directions around a circle centered on the hand's starting location. Based on a previously validated parsing procedure, end-point errors were segmented into localization and planning errors. Localization errors refer to the existence of systematic biases in the estimation of the initial hand location. These biases can potentially transform a simple pattern of pure amplitude errors into a complex pattern involving both amplitude and direction errors. Results indicated that localization errors were different in the PD patients and the control subjects. This is not surprising knowing both that proprioception is altered in PD patients and that the ability to locate the hand at rest relies mainly on the proprioceptive sense, even when vision is available. Unlike normal subjects, localization errors in PD were idiosyncratic, lacking a consistent pattern across subjects. When the confounding effect of initial hand localization errors was canceled, we found that end-point errors were only due to the implementation of an underscaled movement gain (15%), without direction bias. Interestingly, the level of undershoot was found to increase with the severity of the disease (inferred from the Unified Parkinson's Disease Rating Scale, UPDRS, motor score). We also observed that movement variability was amplified (32%), but only along the main movement axis (extent variability). Direction variability was not significantly different in the patient population and the control group. When considered together, these results support the idea that the basal ganglia are specifically involved in the control of movement amplitude (or of some covariates). We propose that this structure participates in extent planning by modulating cortical activity and/or the tuning of the spinal interneuronal circuits.

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Acknowledgements

Supported by NIH grants NS33704 and NS37470.

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Authors and Affiliations

  1. Space and Action, INSERM U534, 16 av. du Doyen Lepine, 69500, Bron, France

    M. Desmurget & R. S. Turner

  2. Center for Cognitive Neuroscience, Dartmouth College, 6162 Moore Hall, Hanover, NH, 03755, USA

    S. T. Grafton

  3. FPSE, Université de Genève, 40 bd du pont d'Arve, Uni Mail, 1205, Geneva, Switzerland

    P. Vindras

  4. Department of Neurosurgery, UCSF, Box 0520, San Francisco, Calif., USA

    H. Gréa

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  1. M. Desmurget
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  2. S. T. Grafton
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  3. P. Vindras
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  5. R. S. Turner
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Correspondence to M. Desmurget.

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Desmurget, M., Grafton, S.T., Vindras, P. et al. Basal ganglia network mediates the control of movement amplitude. Exp Brain Res 153, 197–209 (2003). https://doi.org/10.1007/s00221-003-1593-3

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