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Drug context differently regulates cocaine versus heroin self-administration and cocaine- versus heroin-induced Fos mRNA expression in the rat

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An Erratum to this article was published on 04 April 2009

Abstract

Rationale

We have previously reported that cocaine self-administration is facilitated in male rats not residing in the test chambers (Non Resident rats) relative to rats living in the test chambers at all times (Resident rats). Surprisingly, the opposite was found for heroin.

Materials and methods

We predicted that, when given access to both cocaine and heroin on alternate days, Non Resident rats would take more cocaine relative to heroin than Resident rats. Heroin (25.0 μg/kg) and cocaine (400 μg/kg), were made alternately available for 14 self-administration sessions, on a fixed ratio (FR) schedule that was progressively increased from FR1 to FR5. Next, some rats underwent a progressive-ratio procedure for heroin and cocaine. The other rats continued to alternate heroin and cocaine self-administration for 12 additional sessions, during which the FR schedule was progressively increased from FR10 to FR100. The second aim of the study was to investigate Fos mRNA expression in Resident and Non Resident rats treated with non-contingent intravenous infusion of “self-administration doses” of heroin (25.0 μg/kg) and cocaine (400 μg/kg).

Results

We found that: (1) drug-taking context differentially modulates intravenous cocaine versus heroin self-administration; (2) very low doses of cocaine and heroin are sufficient to induce Fos mRNA expression in the posterior caudate; (3) drug-administration context differentially modulates cocaine- versus heroin-induced Fos mRNA expression.

Conclusions

Our study indicates that the context of drug taking can play a powerful role in modulating cocaine versus heroin intake in the laboratory rat.

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Acknowledgements

This work was supported by grants from the Sapienza University of Rome (C26A06LHXL and C26F06Y9LL) and from the Italian Ministry for University and Research (PRIN, 2005050334_004). The authors thank Ms. Ilaria Lucchino and Ms. Laura Righetti and for their help with in situ hybridization procedures and data analysis.

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Authors and Affiliations

  1. Department of Physiology and Pharmacology “Vittorio Erspamer”, Sapienza University of Rome, Rome, Italy

    Michele Celentano, Daniele Caprioli, Pasqua Di Pasquale, Veronica Cardillo, Paolo Nencini, Silvana Gaetani & Aldo Badiani

  2. CRiN “Daniel Bovet”, Sapienza University of Rome, Rome, Italy

    Paolo Nencini & Aldo Badiani

  3. Edificio di Farmacologia, Sapienza University of Rome, 5 Piazzale Aldo Moro, 00185, Rome, Italy

    Aldo Badiani

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  1. Michele Celentano
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  2. Daniele Caprioli
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Correspondence to Aldo Badiani.

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An erratum to this article can be found at http://dx.doi.org/10.1007/s00213-009-1531-6

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Celentano, M., Caprioli, D., Di Pasquale, P. et al. Drug context differently regulates cocaine versus heroin self-administration and cocaine- versus heroin-induced Fos mRNA expression in the rat. Psychopharmacology 204, 349–360 (2009). https://doi.org/10.1007/s00213-009-1467-x

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