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Functional relations between the cortical gustatory area and the amygdala: Electrophysiological and behavioral studies in rats

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The functional interconnections between the cortical gustatory area (CGA) and the amygdala were examined by electrophysiological and behavioral experiments in rats. The cortical neurons responsive to taste stimuli applied to the anterior part of the tongue were located in the Vth layer of the agranular insular cortex. Of a total of 27 cortical neurons recorded, 10 showed facilitatory and/or inhibitory responses with the mean onset latency of about 20 msec to electrical stimulation of the ipsilateral amygdala. On the other hand, of 18 amygdaloid neurons responsive to taste stimuli, 13 showed facilitatory and/or inhibitory responses to electrical shocks to the ipsilateral CGA, with a mean latency of about 16 ms. No cortical and amygdaloid neurons sampled responded antidromically to the electrical stimulation. These results suggest the existence of mutual polysynaptic fiber connections between the CGA and the amygdala. The behavioral experiment was performed by means of a conditioned taste aversion (CTA) technique. After acquisition of CTA to sucrose solution by pairing it with an i.p. injection of LiCl which produces sickness, bilateral small knife cuts between the CGA and the amygdala in the perirhinal region disrupted retention of CTA. Thus, these interconnections may play some role in association of taste-related cognitive processes with feeding behavior.

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References

  • Azuma S, Yamamoto T, Kawamura Y (1984) Studies on gustatory responses of amygdaloid neurons in rats. Exp Brain Res 56: 12–22

    Google Scholar 

  • Berk ML, Finkelstein JA (1982) Efferent connections of the lateral hypothalamic area of the rat: An autoradiographic investigation. Brain Res Bull 8: 511–526

    Google Scholar 

  • Block CH, Schwartzbaum JS (1983) Ascending efferent projections of the gustatory parabrachial nuclei in the rabbit. Brain Res 259: 1–9

    Google Scholar 

  • Braun JJ, Kiefer SW, Ouellet JV (1981) Psychic ageusia in rats lacking gustatory neocortex. Exp Neurol 72: 711–716

    Google Scholar 

  • Braun JJ, Lasiter PS, Kiefer SW (1982) The gustatory neocortex of the rat. Physiol Psychol 10: 13–45

    Google Scholar 

  • Burešová O (1978) Neocortico-amygdalar interaction in the conditioned taste aversion in rats. Activ Nerv Sup (Praha) 20: 224–230

    Google Scholar 

  • Fitzgerald RE, Burton MJ (1983) Neophobia and conditioned taste aversion deficits in the rat produced by undercutting temporal cortex. Physiol Behav 30: 203–206

    Google Scholar 

  • Kawamura Y, Kasahara Y, Funakoshi M (1970) A possible mechanism for rejection behavior to strong salt solution. Physiol Behav 5: 67–74

    Google Scholar 

  • Kiefer SW, Grijalva CV (1980) Taste reactivity in rats following lesions of the zona incerta or amygdala. Physiol Behav 25: 549–554

    Google Scholar 

  • Kita H, Oomura Y (1981) Functional synaptic interconnections between the lateral hypothalamus and frontal and gustatory cortices in the rat. In: Katsuki Y, Norgren R, Sato M (eds) Brain mechanisms of sensation. Wiley, New York, pp 307–322

    Google Scholar 

  • Kita H, Oomura Y (1982a) An HRP study of the afferent connections to rat medial hypothalamic region. Brain Res Bull 8: 53–62

    Google Scholar 

  • Kita H, Oomura Y (1982b) An HRP study of the afferent connections to rat lateral hypothalamic region. Brain Res Bull 8: 63–71

    Google Scholar 

  • Krettek JE, Price JL (1977) Projections from the amygdaloid complex to the cerebral cortex and thalamus in the rat and cat. J Comp Neurol 172: 687–722

    Google Scholar 

  • Lasiter PS (1982) Cortical substrates of taste aversion learning: Direct amygdalocortical projections to the gustatory neocortex do not mediate conditioned taste aversion learning. Physiol Psychol 10: 377–383

    Google Scholar 

  • Lasiter PS, Glanzman DL (1982) Cortical substrates of taste aversion learning: Dorsal prepiriform (insular) lesions disrupt taste aversion learning. J Comp Physiol Psychol 96: 376–392

    Google Scholar 

  • Lasiter PS, Glanzman DL, Mensah PA (1982) Direct connectivity between pontine taste areas and gustatory neocortex in rat. Brain Res 234: 111–121

    Google Scholar 

  • Makous W, Nord S, Oakley B, Pfaffmann C (1963) The gustatory relay in the medulla. In: Zotterman Y (ed) Olfaction and taste. Pergamon, London, pp 381–393

    Google Scholar 

  • Nachman M, Ashe JH (1974) Effects of basolateral amygdala lesions on neophobia, learned taste aversions and sodium appetite in rats. J Comp Physiol Psychol 87: 622–643

    Google Scholar 

  • Nomura S, Mizuno N, Itoh K, Matsuda K, Sugimoto T, Nakamura Y (1979) Localization of parabrachial nucleus neurons projecting to the thalamus or the amygdala in the cat using horseradish peroxidase. Exp Neurol 64: 375–385

    Google Scholar 

  • Norgren R (1974) Gustatory afferents to ventral forebrain. Brain Res 81: 285–295

    Google Scholar 

  • Norgren R (1976) Taste pathways to hypothalamus and amygdala. J Comp Neurol 166: 17–30

    Google Scholar 

  • Norgren R, Grill HJ (1976) Efferent distribution from the cortical gustatory area in rats. Neuroscience Abst 2: 124

    Google Scholar 

  • Norgren R, Leonard CM (1971) Taste pathways in rat brainstem. Science 173: 1136–1139

    Google Scholar 

  • Norgren R, Leonard CM (1973) Ascending central gustatory pathways. J Comp Neurol 150: 217–238

    Google Scholar 

  • Ogawa H, Kaisaku J (1982) Physiological characteristics of the solitario-parabrachial relay neurons with tongue afferent inputs in rats. Exp Brain Res 48: 362–368

    Google Scholar 

  • Oomura Y, Ono T (1982) Mechanism of inhibition by the amygdala in the lateral hypothalamic area of rats. Brain Res Bull 8: 653–666

    Google Scholar 

  • Ottersen OP (1982) Connections of the amygdala of the rat. IV. Corticoamygdaloid and intraamygdaloid connections as studied with axonal transport of horseradish peroxidase. J Comp Neurol 205: 30–48

    Google Scholar 

  • Ottersen OP, Ben-Ari Y (1979) Afferent connections to the amygdaloid complex of the rat and cat. I. Projections from the thalamus. J Comp Neurol 187: 401–424

    Google Scholar 

  • Pfaffmann C, Norgren R, Grill HJ (1977) Sensory affect and motivation. Ann NY Acad Sci 290: 18–34

    Google Scholar 

  • Price JL, Amaral DG (1981) An autoradiographic study of the projections of the central nucleus of the monkey amygdala. J Neurosci 1: 1242–1260

    CAS  PubMed  Google Scholar 

  • Rhoton AL (1968) Afferent connections of the facial nerve. J Comp Neurol 133: 89–100

    Google Scholar 

  • Saper CB (1982) Convergence of autonomic and limbic connections in the insular cortex of the rat. J Comp Neurol 210: 163–173

    Google Scholar 

  • Schwartz M, Teitelbaum P (1974) Dissociation between learning and remembering in rats with lesions in the lateral hypothalamus. J Comp Physiol Psychol 87: 384–398

    Google Scholar 

  • Shipley MT (1982) Insular cortex projection to the nucleus of the solitary tract and brainstem visceromotor regions in the mouse. Brain Res Bull 8: 139–148

    Google Scholar 

  • Torvik A (1956) Afferent connections to the sensory trigeminal nuclei, the nucleus of the solitary tract and adjacent structures. An experimental study in the rat. J Comp Neurol 106: 51–141

    Google Scholar 

  • Turner BH (1981) The cortical sequence and terminal distribution of sensory related afferents to the amygdaloid complex of the rat and monkey. In: Ben-Ari Y (ed) The amygdaloid complex. Elsevier, Amsterdam, pp 51–62

    Google Scholar 

  • Turner BH, Herkenham M (1981) An autoradiographic study of thalamo-amygdaloid connections in the rat. Anat Rec 199: 260A

  • Veening JG (1978) Cortical afferents of the amygdaloid complex in the rat: An HRP study. Neurosci Lett 8: 191–195

    Google Scholar 

  • Wolf G (1968) Projections of thalamic and cortical gustatory areas in the rat. J Comp Neurol 132: 519–530

    Google Scholar 

  • Yamamoto T, Azuma S, Kawamura Y (1981a) Significance of cortical-amygdalar-hypothalamic connections in retention of conditioned taste aversion in rats. Exp Neurol 74: 758–768

    Google Scholar 

  • Yamamoto T, Azuma S, Kawamura Y (1983) Interconnection between the cortical gustatory area and the amygdala. Neurosci Lett Suppl 13: s48

    Google Scholar 

  • Yamamoto T, Matsuo R, Kawamura Y (1980a) Localization of cortical gustatory area in rats and its role in taste discrimination. J Neurophysiol 44: 440–455

    Google Scholar 

  • Yamamoto T, Matsuo R, Kawamura Y (1980b) The pontine taste area in the rabbit. Neurosci Lett 16: 5–9

    Google Scholar 

  • Yamamoto T, Matsuo R, Kawamura Y (1980c) Corticofugal effects on the activity of thalamic taste cells. Brain Res 193: 258–262

    Google Scholar 

  • Yamamoto T, Yuyama N, Kawamura Y (1980d) Responses of cortical taste cells and chorda tympani fibers to anodal D.C. stimulation of the tongue in rats. Exp Brain Res 40: 63–70

    Google Scholar 

  • Yamamoto T, Yuyama N, Kawamura Y (1981b) Cortical neurons responding to tactile, thermal and taste stimulations of the rat's tongue. Brain Res 221: 202–206

    Google Scholar 

  • Yamamoto T, Yuyama N, Kato T, Kawamura Y (1984) Gustatory responses of cortical neurons in rats. I. Response characteristics. J Neurophysiol 51: 616–635

    Google Scholar 

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Authors and Affiliations

  1. Department of Oral Physiology, Osaka University, Faculty of Dentistry, 1-8 Yamadaoka, Suita, 565, Osaka, Japan

    T. Yamamoto, S. Azuma & Y. Kawamura

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  1. T. Yamamoto
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  2. S. Azuma
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  3. Y. Kawamura
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Yamamoto, T., Azuma, S. & Kawamura, Y. Functional relations between the cortical gustatory area and the amygdala: Electrophysiological and behavioral studies in rats. Exp Brain Res 56, 23–31 (1984). https://doi.org/10.1007/BF00237438

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  • DOI: https://doi.org/10.1007/BF00237438

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