Abstract
The effects of dopamine hydrochloride (DA) on the releases of LHRH and LH were examined in a serial sequential double chamber perifusion system by perifusing the mediobasal hypothalamus including the preoptic area and/or pituitaries excised from diestrus female rats. DA, perif used at a dose of 4.2 × 10−4 M, significantly (p < 0.05) lowered LH secretion from the pituitary in series with the hypothalamus 40–80% below the preinfusion level, but it had no effect on LH efflux from the pituitary perifused alone. DA also significantly (p < 0.05) reduced the LHRH level 20–40% below the initial level. Perifusion with the DA receptor blocker haloperidol at a concentration of 10−6 M abolished the suppressive effect of DA on LH secretion. These findings indicate that DA suppressed hypothalamic LHRH release, resulting in decrease in LH secretion from the pituitary in diestrus rats.
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Tasaka, K., Miyake, A., Sakumoto, T. et al. Dopamine decreases release of luteinizing hormone releasing hormone from superfused rat mediobasal hypothalamus. J Endocrinol Invest 8, 373–376 (1985). https://doi.org/10.1007/BF03348517
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DOI: https://doi.org/10.1007/BF03348517