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Evidence for a role for dopamine in the diazepam locomotor stimulating effect

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Abstract

It is well known that benzodiazepines produce dependence in humans and locomotor stimulation in experimental animals. In this study the possible involvement of catecholamines in the diazepam-induced locomotor stimulation in mice were investigated. Diazepam was found to have a biphasic effect; increasing locomotor activity at a low dose (0.25 mg/kg), while decreasing it at higher doses (>0.5 mg/kg). The locomotor stimulating effect of diazepam was effectively blocked by pretreatment with the benzodiazepine receptor antagonist flumazenil, as well as with the catecholamine synthesis inhibitor α-methyltyrosine and the dopamine receptor antagonists haloperidol, spiperone and SCH 23390. Taken together, these data indicate that the locomotor stimulating effect observed after low doses of diazepam is due to activation of brain dopaminergic systems involved in locomotor activity. The observations are discussed in relation to the hypothesis that dependence-producing drugs activate specific brain reward systems.

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Authors and Affiliations

  1. Department of Pharmacology, University of Göteborg, P.O. Box 33031, S-400 33, Göteborg, Sweden

    Bo Söderpalm, Lennart Svensson, Peter Hulthe, Kenn Johannessen & Jörgen A. Engel

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  1. Bo Söderpalm
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  2. Lennart Svensson
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  3. Peter Hulthe
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  4. Kenn Johannessen
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  5. Jörgen A. Engel
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Söderpalm, B., Svensson, L., Hulthe, P. et al. Evidence for a role for dopamine in the diazepam locomotor stimulating effect. Psychopharmacology 104, 97–102 (1991). https://doi.org/10.1007/BF02244561

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  • DOI: https://doi.org/10.1007/BF02244561

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