Summary
After lesions were placed in the hippocampal commissures, degenerating terminals could be localized above, inside and beneath the granule cell layer of the contralateral dentate gyrus. The terminals formed asymmetric synapses with spines, dendritic shafts and somata of granule cells. Degenerating terminals also formed synapses with dendrites and somata of basket cells identified by the Golgi-electron microscope technique. These basket cells were located either at the hilar border of the granule cell layer or in the molecular layer and each formed an axonal plexus around the somata and proximal dendrites of granule cells. These observations provide an anatomical basis for the recently described feed-forward inhibition in this brain region.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Andersen, P. (1975) Organization of the hippocampal neurons and their interconnections. InThe Hippocampus, Vol. 1,Structure and Development (edited byIsaacson, R. L. &Pribram, K. H.), pp. 155–75. New York: Plenum Press.
Barber, R. &Saito, K. (1976) Light microscopic visualization of GAD and GABA-T in immunocytochemical preparations of rodent C.N.S. InGABA in Nervous System Function (edited byRoberts, E., Chase, T. N. &Tower, D. B.), pp. 113–32. New York: Raven Press.
Berger, W. B., Semple-Rowland, S. &Bassett, J. L. (1981) Hippocampal polymorph neurons are the cells of origin for ipsilateral association and commissural afferents to the dentate gyrus.Brain Research 215, 329–36.
Blackstad, T. W. (1965) Mapping of experimental axon degeneration by electron microscopy of Golgi preparations.Zeitschrift für Zellforschung und mikroskopische Anatomie 67, 819–934.
Buzsáki, G. &Eidelberg, E. (1981) Commissural projection to the dentate gyrus of the rat: evidence for feed-forward inhibition.Brain Research 230, 346–50.
Douglas, R. M., McNaughton, B. L. &Goddard, G. V. (1983) Commissural inhibition and facilitation of granule cell discharge in fascia dentata.Journal of Comparative Neurology 219, 285–94.
Fairén, A., Peters, A. &Saldanha, J. (1977) A new procedure for examining Golgi impregnated neurons by light and electron microscopy.Journal of Neurocytology 6, 311–37.
Frotscher, M. &Zimmer, J. (1983) Commissural fibers terminate on non-pyramidal neurons in the guinea pig hippocampus — a combined Golgi-EM degeneration study.Brain Research 265, 289–93.
Gottlieb, D. I. &Cowan, W. M. (1973) Autoradiographic studies of the commissural and ipsilateral association connections of the hippocampus and dentate gyrus of the rat. I. The commissural connections.Journal of Comparative Neurology 149, 393–422.
Hjorth-Simonsen, A. &Laurberg, S. (1977) Commissural connections of the dentate area in the rat.Journal of Comparative Neurology 174, 591–606.
Kishi, K., Stanfield, B. B. &Cowan, W. M. (1980) A quantitative EM autoradiographic study of the commissural and associational connections of the dentate gyrus in the rat.Anatomy and Embryology 160, 173–86.
Laatsch, R. H. &Cowan, W. M. (1966) Electron microscopic studies of the dentate gyrus of the rat. II. Degeneration of commissural afferents.Journal of Comparative Neurology 130, 241–62.
Laurberg, S. (1979) Commissural and intrinsic connections of the rat hippocampus.Journal of Comparative Neurology 184, 685–708.
Ribak, C. E. &Anderson, L. (1980) Ultrastructure of the pyramidal basket cells in the dentate gyrus of the rat.Journal of Comparative Neurology 192, 903–16.
Ribak, C. E. &Seress, L. (1982) Commissural axons synapse with identified basket cells in the rat dentate gyrus: A combined degeneration-Golgi-electron microscopic study.Society for Neuroscience 8, 836 Abs.
Ribak, C. E. &Seress, L. (1983) Five types of basket cells in the hippocampal dentate gyrus. A combined Golgi and electron microscopic study.Journal of Neurocytology 12, 577–97.
Ribak, C. E., Vaughn, J. E. &Saito, K. (1978) Immunocytochemical localization of glutamic acid decarboxylase in neuronal somata following colchicine inhibition of axonal transport.Brain Research 140, 315–32.
Seress, L. (1978) Pyramid-like basket cells in the granular layer of the dentate gyrus in the rat.Journal of Anatomy 127, 163–68.
Seress, L. &Pokorny, J. (1981) Structure of the granular layer of the rat dentate gyrus. A light microscopic and Golgi study.Journal of Anatomy 133, 181–95.
Seress, L. &Ribak, C. E. (1983) GABAergic cells in the dentate gyrus appear to be local circuit and projection neurons.Experimental Brain Research 50, 173–82.
Seroogy, K. B., Seress, L. &Ribak, C. E. (1983) Ultrastructure of commissural neurons of the hilar region in the hippocampal dentate gyrus.Experimental Neurology 82, 594–608.
Voneida, T. J., Vardaris, R. M., Fish, S. E. &Reiheld, C. T. (1981) The origin of the hippocampal commissure in the rat.Anatomical Record 201, 91–103.
West, J. R., Nornes, H. O., Barnes, C. L. &Bronfenbrenner, M. (1979) The cells of origin of the commissural afferents to the area dentata in the mouse.Brain Research 160, 203–15.
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Seress, L., Ribak, C.E. Direct commissural connections to the basket cells of the hippocampal dentate gyrus: anatomical evidence for feed-forward inhibition. J Neurocytol 13, 215–225 (1984). https://doi.org/10.1007/BF01148116
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF01148116