Skip to main content
Log in

Calcium signalling in oligodendrocytes

  • Published:
Neurophysiology Aims and scope

Abstract

Generation of calcium signal in mammalian oligodendrocytes is a result of two different mechanisms, namely: (i) transmembrane calcium influx via voltage-operated calcium channels, and (ii) calcium release from IP3-sensitive internal calcium stores. The oligodendrocytes express two types of voltage-operated calcium channels with different voltage-dependence. The expression of calcium channels undergoes marked changes during the development of the oligodendrocytes. The cytoplasmic calcium release from internal depots can be triggered by the activation of P2 metabotropic purinoreceptors.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. K. Krnjevitch, M. E. Morris, and N. Ropert, “Changes in free calcium ion concentration recorded inside hippocampal pyramidal cellsin situ,”Brain Res.,374, 1–11 (1986).

    PubMed  Google Scholar 

  2. M. E. Morris, K. Krnjevic, and J. F. MacDonald, “Changes in intracellular free Ca ion concentration evoked by electrical activity in cat spinal neuronsin situ,”Neuroscience,14, 563–580 (1985).

    PubMed  Google Scholar 

  3. B. A. MacVicar, “Voltage-dependent calcium channels in glial cells,”Science,226, 1345–1347 (1984).

    PubMed  Google Scholar 

  4. B. A. Barres, L. L. Y. Chun, and D. P. Corey, “Ion channel expression by white matter glia: Type 2 astrocytes and oligodendrocytes,”Glia,1, 10–30 (1988).

    PubMed  Google Scholar 

  5. B. A. Barres, L. L. Y. Chun, and D. P. Corey, “A calcium current in cortical astrocytes: induction by cAMP and neurotransmitters, and permissive effect of serum factors,”J. Neurosci.,9, 3169–3175 (1989).

    PubMed  Google Scholar 

  6. I. Sommer and M. Schachner, “Monoclonal antibodies (O10 to O4) to oligodendrocyte surfaces: an immunocytological study in the central nervous system,”Dev. Biol.,83, 311–323 (1983).

    Google Scholar 

  7. I. Sommer and M. Schachner, “Cells that are O4 antigen positive and O1-antigen negative differentiate into O1 antigen-positive oligodendrocytes,”Neurosci. Lett.,29, 183–188 (1982).

    PubMed  Google Scholar 

  8. G. Von Blankenfeld, A. Verkhratskii (Verkhratsky), and H. Kettenmann, “Ca2+ channel expression in the oligodendrocyte lineage,”Eur. J. Neurosci.,4, 1035–1048 (1992).

    PubMed  Google Scholar 

  9. A. N. Verkhratskii (Verkhratsky), J. Trotter, and H. Kettenmann, “Cultured glial precursor cells from mouse cortex express two types of calcium currents,”Neurosci. Lett.,112, 194–198 (1990).

    PubMed  Google Scholar 

  10. H. Sontheimer, J. Trotter, M. Schahner, and H. Kettenmann, “Developmental regulation of channel expression in cultured oligodendrocytes,”Neuron,2, 1135–1145 (1989).

    PubMed  Google Scholar 

  11. P. M. Dunn and A. G. H. Blakeley, “Suramin: a reversible P2-purinoreceptor antagonist in the mouse vas deferens,”Br. J. Pharmacol.,93, 243–245 (1988).

    PubMed  Google Scholar 

  12. M. Fill and R. Coronado, “Ryanodine receptor channel of sarcoplasmic reticulum,”Trends Neurosci.,11, 453–457 (1988).

    PubMed  Google Scholar 

  13. P. S. McPherson and K. P. Campbell, “The ryanodine receptor/Ca2+ release channel,”J. Biol. Chem., (1993)268, 13765–13768.

    PubMed  Google Scholar 

  14. M. J. Berridge and R. F. Irvine, “Inositol phosphate and cell signalling,”Nature,341, 197–205 (1989).

    PubMed  Google Scholar 

  15. M. J. Berridge, “Inositoltrisphosphate and calcium signalling,”Nature,361, 315–325 (1993).

    PubMed  Google Scholar 

  16. Ch. D. Ferris and S. H. Snyder, “Inositol 1,4,5-trisphosphate-activated calcium channels,”Annu. Rev. Physiol.,54, 469–488 (1992).

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Additional information

Neirofiziologiya/Neurophysiology, Vol. 26, No. 1, pp. 26–31, January–February, 1994.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Kettenmann, H., Kirishchuk, S. & Verkhratskii, A. Calcium signalling in oligodendrocytes. Neurophysiology 26, 21–25 (1994). https://doi.org/10.1007/BF01059988

Download citation

  • Received:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF01059988

Keywords

Navigation