Abstract
Generation of calcium signal in mammalian oligodendrocytes is a result of two different mechanisms, namely: (i) transmembrane calcium influx via voltage-operated calcium channels, and (ii) calcium release from IP3-sensitive internal calcium stores. The oligodendrocytes express two types of voltage-operated calcium channels with different voltage-dependence. The expression of calcium channels undergoes marked changes during the development of the oligodendrocytes. The cytoplasmic calcium release from internal depots can be triggered by the activation of P2 metabotropic purinoreceptors.
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K. Krnjevitch, M. E. Morris, and N. Ropert, “Changes in free calcium ion concentration recorded inside hippocampal pyramidal cellsin situ,”Brain Res.,374, 1–11 (1986).
M. E. Morris, K. Krnjevic, and J. F. MacDonald, “Changes in intracellular free Ca ion concentration evoked by electrical activity in cat spinal neuronsin situ,”Neuroscience,14, 563–580 (1985).
B. A. MacVicar, “Voltage-dependent calcium channels in glial cells,”Science,226, 1345–1347 (1984).
B. A. Barres, L. L. Y. Chun, and D. P. Corey, “Ion channel expression by white matter glia: Type 2 astrocytes and oligodendrocytes,”Glia,1, 10–30 (1988).
B. A. Barres, L. L. Y. Chun, and D. P. Corey, “A calcium current in cortical astrocytes: induction by cAMP and neurotransmitters, and permissive effect of serum factors,”J. Neurosci.,9, 3169–3175 (1989).
I. Sommer and M. Schachner, “Monoclonal antibodies (O10 to O4) to oligodendrocyte surfaces: an immunocytological study in the central nervous system,”Dev. Biol.,83, 311–323 (1983).
I. Sommer and M. Schachner, “Cells that are O4 antigen positive and O1-antigen negative differentiate into O1 antigen-positive oligodendrocytes,”Neurosci. Lett.,29, 183–188 (1982).
G. Von Blankenfeld, A. Verkhratskii (Verkhratsky), and H. Kettenmann, “Ca2+ channel expression in the oligodendrocyte lineage,”Eur. J. Neurosci.,4, 1035–1048 (1992).
A. N. Verkhratskii (Verkhratsky), J. Trotter, and H. Kettenmann, “Cultured glial precursor cells from mouse cortex express two types of calcium currents,”Neurosci. Lett.,112, 194–198 (1990).
H. Sontheimer, J. Trotter, M. Schahner, and H. Kettenmann, “Developmental regulation of channel expression in cultured oligodendrocytes,”Neuron,2, 1135–1145 (1989).
P. M. Dunn and A. G. H. Blakeley, “Suramin: a reversible P2-purinoreceptor antagonist in the mouse vas deferens,”Br. J. Pharmacol.,93, 243–245 (1988).
M. Fill and R. Coronado, “Ryanodine receptor channel of sarcoplasmic reticulum,”Trends Neurosci.,11, 453–457 (1988).
P. S. McPherson and K. P. Campbell, “The ryanodine receptor/Ca2+ release channel,”J. Biol. Chem., (1993)268, 13765–13768.
M. J. Berridge and R. F. Irvine, “Inositol phosphate and cell signalling,”Nature,341, 197–205 (1989).
M. J. Berridge, “Inositoltrisphosphate and calcium signalling,”Nature,361, 315–325 (1993).
Ch. D. Ferris and S. H. Snyder, “Inositol 1,4,5-trisphosphate-activated calcium channels,”Annu. Rev. Physiol.,54, 469–488 (1992).
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Neirofiziologiya/Neurophysiology, Vol. 26, No. 1, pp. 26–31, January–February, 1994.
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Kettenmann, H., Kirishchuk, S. & Verkhratskii, A. Calcium signalling in oligodendrocytes. Neurophysiology 26, 21–25 (1994). https://doi.org/10.1007/BF01059988
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DOI: https://doi.org/10.1007/BF01059988