Summary
The activity of pontomedullary reticular, vestibular, and prepositus neurons has been recorded in the alert cat during spontaneous and vestibular-induced eye movements. Neurons were identified by their antidromic activation from the abducens nucleus. Spikes of these neurons were used to trigger the recording of field potentials in the abducens nucleus. The analysis by post-spike averaging of the field potentials showed the presence of a trifold system of reciprocal (excitatory and inhibitory) direct projections that originated in the above nuclei and terminated in the abducens nucleus with a distinctly graded effectiveness. This trifold afferent system is involved in the generation of fast eye movements, slow compensatory movements of vestibular origin, and eye fixation, respectively.
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References
Baker R, Spencer RF (1981) Synthesis of horizontal conjugate eye movement signals in the abducens nucleus. Jpn J EEG EMG 31: 39–49
Delgado-García JM, del Pozo F, Baker R (1986) Behavior of neurons in the abducens nucleus of the alert cat. I. Motoneurons. Neuroscience 4: 929–952
Destombes J, Rouvière A (1981) Ultrastructural study of vestibular and reticular projections to the abducens nucleus. Exp Brain Res 43: 253–260
Fuchs AF, Kaneko CRS, Scudder CA (1985) Brain control of saccadic eye movements. Annu Rev Neurosci 8: 307–337
Grantyn A, Ong-Meang Jacques V, Berthoz A (1987) Reticulo-spinal neurons participating in the control of synergic eye and head movements during orienting in the cat. II. Morphological properties as revealed by intra-axonal injections of horse-radish peroxidase. Exp Brain Res 66: 355–377
Hikosaka O, Igusa Y, Imai H (1980) Inhibitory connections of nystagmus-related reticular burst neurons with neurons in the abducens prepositus hypoglossi and vestibular nuclei in the cat. Exp Brain Res 39: 301–311
Hikosaka O, Igusa Y, Nakao S, Shimazu H (1978) Direct inhibitory synaptic linkage of pontomedullary reticular burst neurons with abducens motoneurons in the cat. Exp Brain Res 33: 337–352
Hubbard JI, Llinás R; Quastel DMJ (1969) Electrophysiological analysis of synaptic transmission. Arnold, London
Igusa A, Sasaki S, Shimazu H (1980) Excitatory premotor burst neurons in the cat pontine reticular formation related to the quick phase of vestibular nystagmus. Brain Res 182: 451–456
Ishizuka N, Mannem H, Sasaki S, Shimazu H (1980) Axonal branches and terminations in the cat abducens nucleus of secondary vestibular neurons in the horizontal canal system. Neurosci Lett 16: 143–148
Jankowska E, Roberts WJ (1972) Synaptic actions of single interneurons mediating reciprocal Ia inhibition of motoneurons. J Physiol (Lond) 222: 623–642
Langer T, Kaneko CR, Scudder CA, Fuchs AF (1986) Afferents to the abducens nucleus in the monkey and cat. J Comp Neurol 245: 379–400
López-Barneo J, Darlot C, Berthoz A, Baker R (1982) Neuronal activity in prepositus nucleus correlated with eye movement in the alert cat. J Neurophysiol 47: 329–352
Lorente de Nó R (1933) Vestibulo-ocular reflex arc. Arch Neurol Psychiatry 30: 244–291
Maciewicz RJ, Eagen K, Kaneko CRS, Highstein SM (1977) Vestibular and medullary brain stem afferents to the abducens nucleus of the cat. Brain Res 123: 229–240
McCrea RA, Baker R (1985) Anatomical connections of the nucleus prepositus of the cat. J Comp Neurol 237: 360–376
McCrea RA, Yoshida K, Berthoz A, Baker R (1980) Eye movement related activity and morphology of second order vestibular neurons terminating in the cat abducens nucleus. Exp Brain Res 40: 468–473
Mendell LM, Henneman E (1971) Terminals of single Ia fibers: location, density and distribution within a pool of 300 homogenous motoneurons. J Neurophysiol 34: 171–187
Spencer RF, Sterling P (1977) An electron microscope study of motoneurons and interneurons in the cat abducens nucleus identified by retrograde intraaxonal transport of horseradish peroxidase. J Comp Neurol 176: 65–86
Strassman A, Highstein SM, McCrea RA (1986) Anatomy and physiology of saccadic burst neurons in the alert squirrel monkey. I. Excitatory burst neurons. J Comp Neurol 249: 337–357
Yoshida Y, McCrea R, Berthoz A, Vidal PP (1982) Morphological and physiological characteristics of inhibitory burst neurons controlling horizontal rapid eye movements in the alert cat. J Neurophysiol 48: 761–784
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Escudero, M., Delgado-García, J.M. Behavior of reticular, vestibular and prepositus neurons terminating in the abducens nucleus of the alert cat. Exp Brain Res 71, 218–222 (1988). https://doi.org/10.1007/BF00247538
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DOI: https://doi.org/10.1007/BF00247538