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Thalamocortical transformation of responses to complex auditory stimuli

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Summary

In unanesthetized guinea pigs, thalamic (CGM), and cortical (auditory I) neurons were recorded simultaneously. Nine of 69 neuron pairs showed a positive cross-correlation of their spontaneous activities, with increased discharge probability of the cortical neuron beginning 2–5 ms after the discharge of the CGM-neuron. The individual neurons of such pairs had an identical CF and the same spectral responsiveness.

The responses of cortical neurons to pure tones were much more phasic than those of the corresponding CGM-neurons. Thalamic neurons could be driven up to much higher AM- and FM-modulation frequencies (100 Hz) than cortical neurons, which usually ceased to follow AM-frequencies above 20 Hz. Stronger or weaker suppression of tonic response components in cortical and thalamic neurons and the lower AM-range of cortical neurons is related to stronger or weaker intracortical and intrathalamic inhibition respectively. Response characteristics to FM-stimuli are similar to those of AM-stimuli.

All CGM and cortical neurons responded to a variety of natural calls of the same or of other species. Responses of CGM-cells represented more components of a call than cortical cells even if the two cells were synaptically connected. In cortical cells, repetitive elements of a call were not represented if the repetition rate was too high. High modulation frequencies within a call, such as those of the fundamental frequency, could still be separated in the response of some CGM-neurons, but never in those of cortical neurons. Both CGM and cortical cells responded essentially to transients (amplitude or frequency modulations) within a call, if spectral components of such elements were within the spectral sensitivity of the cell. Spectral components outside the spectral sensitivity range could result in suppression of spontaneous discharge rate. Responses of cortical and CGM-cells, and thus the representation of call elements by neuronal responses, varied with the intensity of a call. It is suggested that, at higher levels of the auditory system, essential information about the temporal features of complex sounds may be represented by neural responses to transients in various spectral regions.

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References

  • Abeles M, Goldstein MH (1972) Responses of single units in the primary auditory cortex of the cat to tone and tone pairs. Brain Res 42: 337–352

    Google Scholar 

  • Cleland BG, Dubin RW, Levick WR (1971) Simultaneous recordings of input and output of lateral geniculate neurons. Nature (New Biol) 231: 191–192

    Google Scholar 

  • Creutzfeldt OD (1977) Generality of the functional structure of the neocortex. Naturwissenschaften 64: 507–517

    Google Scholar 

  • Creutzfeldt O, Ito M (1968) Functional synaptic organization of primary visual cortex neurons in the cat. Exp Brain Res 6: 324–352

    Google Scholar 

  • Creutzfeldt O, Kuhnt U, Benevento L (1974) An intracellular analysis of visual cortical responses to moving stimuli: Responses in a co-operative neuronal network. Exp Brain Res 21: 251–274

    Google Scholar 

  • Creutzfeldt O, Lux HD, Watanabe S (1966) Electrophysiology of cortical nerve cells. In: Purpura DP, Yahr MD (eds) The thalamus. Columbia University Press, New York, pp 209–231

    Google Scholar 

  • Creutzfeldt OD, Nothdurft HC (1978) Representation of complex visual stimuli in the brain. Naturwissenschaften 65: 307–318

    Google Scholar 

  • Dubin MW, Cleland BG (1977) The organization of visual inputs to interneurones of the lateral geniculate nucleus of the cat. J Neurophysiol 40: 410–427

    Google Scholar 

  • Dunlop CW, Itzkowic DJ, Aitkin LM (1969) Tone-burst response patterns of single units in the cats medial geniculate cortex. Brain Res 16: 149–164

    Google Scholar 

  • Etholm B, Gjerstad LI, Skrede KK (1976) Size and duration of inhibition in the medial geniculate body in unanesthetized cats. Acta Otolaryngol 81: 102–112

    Google Scholar 

  • Evans EF, Ross HF, Whitfield IC (1965) The spatial distribution of unit characteristic frequency in the primary auditory cortex of the cat. J Physiol (Lond) 179: 238–247

    Google Scholar 

  • Galambos R, Davis H (1943) The response of single auditory nerve fibres to acoustic stimulation. J Neurophysiol 6: 39–57

    Google Scholar 

  • Galambos R (1952) Microelectrode studies on medial geniculate body of cat. III. Response to pure tones. J Neurophysiol 15: 381–400

    Google Scholar 

  • Goldstein MH, Abeles M (1976) Single unit activity in the auditory cortex. In: Keidel WE, Neff WD (eds) Handbook of sensory physiology, Vol V/2. Springer, Berlin Heidelberg New York

    Google Scholar 

  • Funkenstein HH, Winter P (1973) Responses to acoustic stimuli of units in the auditory cortex of awake squirrel monkeys. Exp Brain Res 18: 464–488

    Article  Google Scholar 

  • Hellweg FC, Koch R, Vollrath M (1977) Representation of the cochlea in the neocortex of guinea pigs. Exp Brain Res 29: 467–474

    Google Scholar 

  • Hellweg FC, Schultz W, Creutzfeldt OD (1977) Extracellular and intracellular recordings from cat's cortical whisker projection area: Thalamo-cortical response transformation. J Neurophysiol 40: 463–479

    Google Scholar 

  • Hind JE, Davies PW, Woolsey CN, Benjamin RM, Welkes WS, Thompson RF (1960) Unit activity in the auditory cortex. In: Rasmussen GL, Windle WF (eds) Neural Mechanisms of the Auditory and Vestibular Systems, Chapt 10. Ch. C. Thomas, Springfield, Ill.

    Google Scholar 

  • Katsuki Y, Sumi T, Uchiyama H, Watanabe T (1962) Electric response of auditory neurons in cat to sound stimulation. J Neurophysiol 25: 569–588

    Google Scholar 

  • Kiang NY-S (1965) Discharge patterns of single fibers in the cat's auditory nerve. MIT Press, Cambridge, Mass.

    Google Scholar 

  • Lee BB, Cleland BG, Creutzfeldt OD (1977) The retinal input to cells in area 17 of the cat's cortex. Exp Brain Res 30: 527–538

    Google Scholar 

  • Merzenich MM, Knight PL, Roth GL (1975) Representation of the cochlea within primary auditory cortex in the cat. J Neurophysiol 38: 231–249

    Google Scholar 

  • Møller AR (1969) Unit responses in the rat cochlear nucleus to repetitive transient sounds. Acta Physiol Scand 75: 542–551

    Google Scholar 

  • Møller AR (1972) Coding of amplitude and frequency modulated sounds in the cochlear nucleus of the rat. Acta Physiol Scand 86: 223–238

    Google Scholar 

  • Nacimiento AC, Lux HD, Creutzfeldt OD (1964) Postsynaptische Potentiale von Nervenzellen des motorischen Cortex nach elektrischer Reizung spezifischer und unspezifischer Thalamuskerne. Pflügers Arch 281: 152–169

    Google Scholar 

  • Newman JD (1978) Central nervous system processing of sounds in primates. In: Steklis H, Raleigh MJ (eds) Neurobiology of social communication in primates. An evolutionary perspective. Academic Press, New York

    Google Scholar 

  • Pfeiffer R (1966) Classification of response patterns of spike discharge for units in the cochlear nucleus: Tone-burst stimulation. Exp Brain Res 1: 220–235

    Google Scholar 

  • Ribeaupierre F de, Goldstein MH, Yeni-Komishen G (1972a) Intracellular study of the cat's primary auditory cortex. Brain Res 48: 185–204

    Google Scholar 

  • Ribeaupierre F de, Goldstein MH, Yeni-Komishen G (1972b) Cortical coding of repetitive acoustic pulses. Brain Res 48: 205–225

    Google Scholar 

  • Scheich H (1970) In: Bullock TH (ed) Recognition of complex acoustic signals. Dahlem Konferenzen, Abakon Vlgs. Ges., Berlin

  • Schreiner Chr (1979) Temporal suppression and speech processing. In: Creutzfeldt O, Scheich H, Schreiner Chr (eds) Hearing mechanisms and speech. Exp Brain Res (Suppl II). Springer, Berlin Heidelberg New York

    Google Scholar 

  • Swarbrick L, Whitfield IC (1972) Auditory cortical units selectively responsive to stimulus “shape”. J Physiol (Lond) 224: 68–69P

    Google Scholar 

  • Watanabe T, Katsuki Y (1974) Response patterns of single auditory neurones of the cat to species specific vocalization. Jap J Physiol 24: 135–155

    Google Scholar 

  • Watanabe T, Sakai H (1978) Responses of the cat's collicular auditory neuron to human speech. J Acoust Soc Am 64: 333–337

    Google Scholar 

  • Webster WR, Aitkin LM (1975) Central auditory processing. In: Gazzaniga MS, Blakemore C (eds) Handbook of psychology. Academic Press, New York

    Google Scholar 

  • Whitfield IC, Evans EF (1965) Responses of auditory cortical neurons to stimuli of changing frequency. J Neurophysiol 28: 656–672

    Google Scholar 

  • Winter P, Funkenstein HH (1973) The effect of species specific vocalizations on the discharge of auditory cortical cells in the awake squirrel monkey (saimiri sciureus). Exp Brain Res 18: 489–504

    Google Scholar 

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This work was partially supported by the Deutsche Forschungsgemeinschaft through the Sonderforschungsbereich 33

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Creutzfeldt, O., Hellweg, F.C. & Schreiner, C. Thalamocortical transformation of responses to complex auditory stimuli. Exp Brain Res 39, 87–104 (1980). https://doi.org/10.1007/BF00237072

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