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Transient Receptor Potential Channels pp 615–636Cite as

Role of TRP Channels in Pain Sensation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 704))

Abstract

It is crucial for a living organism to recognize and discern potentially harmful noxious stimuli from innocuous stimuli to avoid hazards in the environment. However, unnecessary or exaggerated nociception is at best unpleasant and often compromises the quality of life. In order to lessen the intensity of nociception or eliminate the pathological pain, it is important to understand the nature of nociception and the mechanisms of hyperalgesia or allodynia. Transient receptor potential (TRP) channels play central roles in nociception under physiological and pathological conditions including inflammation and neuropathy. In this chapter, we will highlight the enormous progress in understanding the role of TRP channels in nociception. We will mainly focus on two TRP channels (TRPV1 and TRPA1) that have been particularly implicated in transducing signals associated with pain sensation, and briefly discuss the role of TRPM8, TRPV3 and TRPV4. We will stress debatable issues that needed to be resolved and provide perspectives for the future studies.

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Acknowledgments

This work was supported by a grant (R0A-2008-000-20101-0) from the National Research Laboratory Program and a grant (2009K001256) from Brain Research Center of the twenty-first century Frontier Research Program, funded by the Ministry of Education, Science and Technology, the Republic of Korea. We thank Gehoon Chung and Alexander J. Davies for helpful comments and English correction in this manuscript.

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Authors and Affiliations

  1. Department of Neural and Pain Sciences, University of Maryland Dental School, Baltimore, MD, USA

    Man-Kyo Chung

  2. Department of Physiology College of Medicine, Hanyang University, Seoul, 133-791, Republic of Korea

    Sung Jun Jung

  3. Department of Neurobiology and Physiology, School of Dentistry Seoul National University, Seoul, 110-749, Republic of Korea

    Seog Bae Oh

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  1. Man-Kyo Chung
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  2. Sung Jun Jung
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  3. Seog Bae Oh
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Correspondence to Seog Bae Oh .

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  1. Dept. Clinical Research & Education, Södersjukhuset, Karolinska Institutet, Stockholm, 118 83, Sweden

    Md. Shahidul Islam

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Chung, MK., Jung, S.J., Oh, S.B. (2011). Role of TRP Channels in Pain Sensation. In: Islam, M. (eds) Transient Receptor Potential Channels. Advances in Experimental Medicine and Biology, vol 704. Springer, Dordrecht. https://doi.org/10.1007/978-94-007-0265-3_33

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