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Molecular and Cellular Mechanisms of Action of Nicotine in the CNS

  • Chapter
Book cover Nicotine Psychopharmacology

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 192))

Abstract

Nicotine achieves its psychopharmacological effects by interacting with nicotinic acetylcholine receptors (nAChRs) in the brain. There are numerous subtypes of nAChR that differ in their properties, including their sensitivity to nicotine, permeability to calcium and propensity to desensitise. The nAChRs are differentially localised to different brain regions and are found on presynaptic terminals as well as in somatodendritic regions of neurones. Through their permeability to cations, these ion channel proteins can influence both neuronal excitability and cell signalling mechanisms, and these various responses can contribute to the development or maintenance of dependence. However, many questions and uncertainties remain in our understanding of these events and their relevance to tobacco addiction. In this chapter, we briefly overview the fundamental characteristics of nAChRs that are germane to nicotine's effects and then consider the cellular responses to acute and chronic nicotine, with particular emphasis on dopamine systems because they have been the most widely studied in the context of nicotine dependence. Where appropriate, methodological aspects are critically reviewed.

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Authors and Affiliations

  1. CNRS UMR7148, Génétique Moléculaire, Neurophysiologie & Comportement Collège de France, 11 place Marcelin Berthelot, Paris Cedex 05, 75231, France

    Jacques Barik

  2. Department of Biology & Biochemistry, University of Bath, Bath, BA2 7AY, UK

    Susan Wonnacott

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  1. Jacques Barik
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  1. Pinney Associates, 3 Bethesda Metro Center, Bethesda, MD, 20814-3472, USA

    Jack E. Henningfield

  2. UCLA Semel Institute for Neuroscience and Human Behavior, 760 Westwood Plaza, Los Angeles, CA, 90024-1759, USA

    Edythe D. London

  3. Center for Brain Research, Bornova, Ege University, Izmir, 35100, Turkey

    Sakire Pogun

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Barik, J., Wonnacott, S. (2009). Molecular and Cellular Mechanisms of Action of Nicotine in the CNS. In: Henningfield, J.E., London, E.D., Pogun, S. (eds) Nicotine Psychopharmacology. Handbook of Experimental Pharmacology, vol 192. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69248-5_7

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