Regular ArticleMorphine-Induced Deficits in Sleep Patterns: Attenuation by Glucose
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2010, Psychiatry ResearchCitation Excerpt :The effects of opioids on sleep architecture appear to be dose-dependent. One study reported that low amounts of morphine produced a decrease of SWS in experimental rats, while REM sleep was only affected at higher doses (Arankowsky-Sandoval and Gold, 1995). Human studies found that single low doses of opioids reduced SWS in healthy adult, and REM sleep remained unchanged (Shaw et al., 2005; Dimsdale et al., 2007).
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