Regular ArticleLong-Term Potentiation Is Increased in the CA1 Area of the Hippocampus of APPswe/ind CRND8 Mice
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2022, Neuroscience and Biobehavioral ReviewsStrain differences in hippocampal synaptic dysfunction in the TgCRND8 mouse model of Alzheimer's disease: Implications for improving translational capacity
2019, Molecular and Cellular NeuroscienceCitation Excerpt :Its protein product, CaMKIIα, has been shown to be required for hippocampal-associated spatial learning (Silva et al., 1992a), memory consolidation (Frankland et al., 2001), and intact hippocampal LTP (Silva et al., 1992b), making it an attractive candidate to potentially explain some of the phenotypic strain differences reported in the literature. Importantly, this is the first examination of basal and synaptic function in the 129 TgCRND8 model, in which several parameters were severely affected by the AD-like mutations, as all prior published studies of synaptic function in this model have been in mice maintained on C3H hybrid backgrounds (Jolas et al., 2002; Kimura et al., 2012; Arrieta-Cruz et al., 2010) or un-specified backgrounds (Tozzi et al., 2015). This may possibly be due in part to C3H being favored in experimental designs due to the increased mortality rate of 129 Tg (25% survival rate by 12 months) relative to C3H Tg mice (50% survival rate by 12 months; (Chishti et al., 2001)) and the resulting difficulties in establishing older experimental groups.
SUMO1 impact on Alzheimer disease pathology in an amyloid-depositing mouse model
2018, Neurobiology of Disease
- 1
To whom correspondence should be addressed. Fax: (908)740-3294. E-mail: [email protected].
- 2
These two authors contributed equally to this work.