Regular ArticleThe Estrogen Receptor Is Not Essential for All Estrogen Neuroprotection: New Evidence from a New Analog
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2011, European Journal of Medicinal ChemistryCitation Excerpt :The extent of cell death was unchanged when the cells were pre-incubated with up to 10 μM 17β-estradiol; however, pre-incubation of the cells with 9 for 12 and 24 h was shown to attenuate cell death in a dose-dependent fashion, with survival close to control levels at 1 μM [28]. The ED50 value of 9 at cloned human estrogen receptors was 100-times greater than the ED50 value of 17β-estradiol (1 nM) [28], which indicates that in 9, the well-established neuroprotective effects of the estrogen group have been decoupled from the estrogen receptor mediated properties [28,29]. The extended pre-incubation times that were required to observe the neuroprotective effects of 9 (12, 24 h) were ascribed to 9 processing membrane-associated radicals in intracellular compartments, which concurs with the higher clogP value of 9, relative 17β-estradiol, which would be more soluble in the cytosol.
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