Regular ArticleThe Role of GSK3β in Regulating Neuronal Differentiation inXenopus laevis
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2020, Cell Stem CellCitation Excerpt :A pilot study was performed in parallel using pools of 8 lines to determine if the multiplex approach could reliably detect neurogenic phenotypes. Indeed, the GSK3β-positive control line among the pool of 8 lines showed an expected neurogenic phenotype (Figure S3C), in agreement with studies in the mouse (Ahn et al., 2014; Marcus et al., 1998). Examination of the MIX30 pools showed robust and comparable efficiencies of neural induction across all autism lines (Figure 3B).
Proneural genes in neocortical development
2013, NeuroscienceCitation Excerpt :Recent studies have revealed that glycogen synthase kinase 3 (GSK3) is a critical regulator of Neurog2 function in the neocortex (Li et al., 2012). This is consistent with the known abilities of GSK3 and other intracellular kinases to modulate bHLH functions in other systems (Marcus et al., 1998; Moore et al., 2002; Ohkawara et al., 2004; Hand et al., 2005; Ge et al., 2006; Ma et al., 2008; Ali et al., 2011; Hindley et al., 2012). Specifically, GSK3 is a proline-directed serine threonine kinase that recognizes threonine–proline (TP) and serine–proline (SP) sites.
The Xenopus Tgfbi is required for embryogenesis through regulation of canonical Wnt signalling
2013, Developmental BiologyCitation Excerpt :The phenotypes we observed for XTgfbi depletion are highly reminiscent of those seen after inhibition of canonical Wnt activity, which has been shown to regulate the induction, differentiation and patterning of multiple dorsal tissues. For example, overexpression of DN-Xwnt-8, DN-Tcf3 or GSK3β inhibits muscle induction and neural differentiation as revealed by reduced MyoD and NBT expression in gastrula and neural plate embryos, respectively (Hoppler et al., 1996; Marcus et al., 1998). Conversely, injection of DN-Tcf3 or DN-Lef1, dramatically promoted neural induction and anterior neural plate fates as evidenced by expansion of Sox2 (Heeg-Truesdell and LaBonne, 2006), similar to our observations.
The dual regulator Sufu integrates Hedgehog and Wnt signals in the early Xenopus embryo
2011, Developmental BiologyFrizzled-10 promotes sensory neuron development in Xenopus embryos
2009, Developmental BiologyExpression of Disabled 1 suppresses astroglial differentiation in neural stem cells
2009, Molecular and Cellular Neuroscience
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To whom correspondence and reprint requests should be addressed at present address: Cell Press, 1050 Massachusetts Ave., MA 02138. Fax: (617) 661-7061. E-mail:[email protected].
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Department of Anatomy, University of Cambridge, Cambridge, CB23DY, UK.