Regular ArticleEffects of Ovariectomy and Estrogen Treatment on Learning and Hippocampal Neurotransmitters in Mice
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Cited by (102)
Chronic adolescent stress causes sustained impairment of cognitive flexibility and hippocampal synaptic strength in female rats
2021, Neurobiology of StressCitation Excerpt :Similarly, Marrocco et al., 2017 found that ovariectomy attenuated stress-induced impairments in behavior but that exogenous treatment with estradiol did not restore the effect and depended on genotype (heterozygous BDNF Val66Met carriers), suggesting a more complex interplay beyond circulating estradiol alone. Interestingly, evidence indicates that ovariectomy induces more male-typic performance on learning and memory tasks (Gibbs and Johnson, 2008; Heikkinen et al., 2002) suggesting a complex role for the endocrine system in cognitive function. Future work is needed to determine the extent to which chronic stress at vulnerable developmental timepoints, particularly for endocrine refinement, may shift the balance between sex-steroid receptors and circulating hormones and subsequent implications for neural function.
Sex differences in pregabalin-seeking like behavior in a conditioned place preference paradigm
2020, Saudi Pharmaceutical JournalIt takes a neural village: Circuit-based approaches for estrogenic regulation of episodic memory
2020, Frontiers in Neuroendocrinology
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