Regular ArticleSystemic Hyperosmolality Improves β-Glucuronidase Distribution and Pathology in Murine MPS VII Brain Following Intraventricular Gene Transfer
References (51)
- et al.
Flow of cerebral interstitial fluid as indicated by the removal of extracellular markers from rat caudate nucleus
Exp. Eye Res.
(1977) - et al.
Expression of Escherichia coli β-galactosidase and rat HPRT in the CNS of Macaca mulatta following adenoviral mediated gene transfer
Exp. Neurol.
(1994) - et al.
Distribution of extracellular tracers in perivascular spaces of the rat brain
Brain Res.
(1991) - et al.
Disappearance of lysosomal storage in spleen and liver of mucopolysaccharidosis VII mice after transplantation of genetically modified bone marrow cells
Blood
(1993) - et al.
Pressure-dependent bulk flow of cerebrospinal fluid into brain
Exp. Neurol.
(1978) - et al.
Beta glucuronidase deficiency: Report of clinical, radiologic, and biochemical features of a new mucopolysaccharidosis
J. Pediatr.
(1973) - et al.
Functional expression of the human angiotensinogen gene in transgenic mice
J. Biol. Chem.
(1994) - et al.
Direct in vivo gene transfer to ependymal cells in the central nervous system using recombinant adenovirus vectors
Nat. Genet.
(1993) Enzyme histochemistry
- et al.
Behavioral consequences of bone marrow transplantation in the treatment of murine mucopolysaccharidosis type VII
J. Clin. Invest.
(1994)
Visual fields in patients with posterior GPi pallidotomy
Neurology
Correction of murine mucopolysaccharidosis type VII (MPS VII) by bone marrow transplantation and gene transfer therapy
Hum. Gene Ther.
Murine mucopolysaccharidosis type VII. Characterization of a mouse with beta-glucuronidase deficiency
J. Clin. Invest.
Junctions between intimately apposed cell membranes in the vertebrate brain
J. Cell Biol.
Efflux of radiolabeled polyethylene glycols and albumin from rat brain
Am. J. Physiol.
Regulation of brain water and electrolytes during acute hyperosmolality in rats
Am. J. Physiol.
Convection of cerebral interstitial fluid and its role in brain volume regulation
Ann. NY Acad. Sci.
Bulk flow of interstitial fluid after intracranial injection of Blue Dextran 2000
Exp. Neurol.
The ependyma: A protective barrier between brain and cerebrospinal fluid
Glia
Effect of Mannitol on Cerebrospinal Fluid Dynamics and Brain Tissue Edema
Anesth. Analg.
Gene expression from recombinant viral vectors in the central nervous system after blood-brain barrier disruption
Neurosurgery
Intraventricular delivery of gene therapy in the fetal pediatric neurogenetic disorder, Canavan's disease
Am. Assoc. Neurol. Surg.
Extensive β-glucuronidase activity in murine CNS after adenovirus mediated gene transfer to brain
Hum. Gene Ther.
Über ein perivasculäres Canalsystem in den nervösen Centralorganen and über dessen Beziehungen zum Lymphsystem
Z. Wiss. Zool.
In vivo transfer of a reporter gene to the retina mediated by an adenoviral vector
Invest. Ophthalmol. Vis. Sci.
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To whom correspondence should be addressed at *Beverly L. Davidson, Ph.D. 200 EMRB, University of Iowa College of Medicine, Iowa City, IA 52242. Fax: (319) 353-5572. E-mail: beverly-davidson@ uiowa.edu.