Regular ArticleNeurotoxic and Neuroprotective Actions of Catecholamines in Cortical Neurons
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2019, Neurochemistry InternationalNeurotransmitter amines and antioxidant agents in neuronal protection against methylmercury-induced cytotoxicity in primary cultures of mice cortical neurons
2018, NeuroToxicologyCitation Excerpt :When applied at concentrations below 30 μM, catecholamines such as dopamine and norepinephrine, promote long-term survival of the dopaminergic neurons. Their protective effect against cell death is connected with decreasing concentrations of intracellular ROS (Troadec et al., 2001) and does not depend on the activation of catecholamine receptors (Noh et al., 1999; Troadec et al., 2001). It is worth to note that the concentration of dopamine used in this work is close to reported physiological concentrations in rat cortex (1,8 μM in basal extracellular rat cortex, which increase 4–6 fold after a depolarizing or chemical challenge; Romero et al., 1998; Díaz-Mataix et al., 2005).
Premature aging in behavior and immune functions in tyrosine hydroxylase haploinsufficient female mice. A longitudinal study
2018, Brain, Behavior, and ImmunityAntioxidant activity of dopamine and L-DOPA in lipid micelles and their cooperation with an analogue of α-tocopherol
2015, Free Radical Biology and MedicineCitation Excerpt :The ability of catecholamines to neutralize free radicals was described in a few works, including theoretical [23] and experimental results (the kinetic studies limited to nonpolar solvents) [24–26]. A direct reaction of catecholamines with free radicals was reported in early studies with a model 2,2-diphenyl-1-picrylhydrazyl radical (dpph•) [19,27]. More recently, reactions of catecholamines with tert-butyloxyl and cumyloxyl radicals (Y•), were studied by Cosa and Scaiano [24] and also by Ohkubo et al. [26], who applied electron paramagnetic resonance (EPR) technique for detection of ortho-semiquinone radical (Ar(OH)O•) formed from adrenaline (Ar(OH)2) during the reaction carried out in propionitrile [26]:Ar(OH)2+Y•→Ar(OH)O•+YH.The semiquinone radical is stabilized by the intramolecular hydrogen bond (HB) involving an oxyl radical moiety, O•, and the hydrogen atom from the adjacent hydroxyl group (O•---HO) [28,29].
Mitochondrial dysfunction mediated by quinone oxidation products of dopamine: Implications in dopamine cytotoxicity and pathogenesis of Parkinson's disease
2011, Biochimica et Biophysica Acta - Molecular Basis of Disease
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