Biochemical and Biophysical Research Communications
Regular ArticleProline-Rich Synapse-Associated Proteins ProSAP1 and ProSAP2 Interact with Synaptic Proteins of the SAPAP/GKAP Family
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2022, Pharmacological ResearchCitation Excerpt :Shank proteins, including Shank1, Shank2, and Shank3, contain several domains, including ankyrin repeat domains, an SH3 domain, a PSD-95/Discs large/Zona occludens-1 (PDZ) domain, a proline-rich region, and a sterile alpha motif domain (Fig. 2). Shank proteins directly interact with many synaptic and signaling molecules, including α-fodrin via its ankyrin repeat domains [34], glutamate receptor-interacting protein 1 (GRIP1) via its SH3 domain [35,36], SAPAP/GKAP via its PDZ domain [33,37], and Homer via its proline-rich region [38,39] (Fig. 1). In addition, Shank proteins indirectly interact with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors with the accessory protein stargazin [40], which is anchored by the PSD-95-SAPAP/GKAP complex to the PDZ domain of the Shank protein [38], and with N-methyl-D-aspartate (NMDA) receptors anchored by the PSD-95-SAPAP/GKAP complex to the PDZ domain of the Shank protein [41] (Fig. 1).
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2019, Comparative Biochemistry and Physiology Part - B: Biochemistry and Molecular Biology
- 1
To whom correspondence should be addressed at Institute of Anatomy, AG Mol Neurobiology, Vesaliusweg 2-4, D-48149 Münster, Germany. Fax: *49-251-8355241. E-mail: [email protected].
- 2
Both authors contributed equally to this paper.