1. Mediates axonal guidance and midline repulsion in developing Drosophila. | 1. Robo, RacGTP, Slit (Lundström et al., 2004; Hu et al., 2005) |
2. Regulates filopodia formation and directional migration of human vascular endothelial cells. | 2. Robo1 and Robo4, Cdc42, IRSp53, MENA, actin nucleation (Kaur et al., 2008) |
3. Delays cell cycle and decreases proliferation of mouse neural stem cell line, C17.2. | 3. p21, decreased progression from G1 to S (Ma and Nowak, 2011) |
4. Promotes apoptosis in C17.2 cells. | 4. BAX, p53 (Ma and Nowak, 2011) |
5. Regulates dendritic spine morphology in embryonic rat hippocampal neurons. | 5. CNK2, Rac1 (Lim et al., 2014) |
6. Decreases neurogenesis in mouse hippocampus. | 6. Rac1, β-catenin (Huang et al., 2016) |
7. Plays a role in learning and memory. | 7. Hippocampal synaptic signaling (Lee et al., 2017) |