Table 2.

Sensitivity to an electrical footshock in the kinase-dead CaMKIIα (K42R)-KI mouse as compared to the wild-type mouse

WTCaMKIIα (K42R)-KI
Step/paw0.032 ± 0.0020.031 ± 0.001
Vocal/run/jump0.061 ± 0.003a0.078 ± 0.003a

  • Threshold currents are expressed in mA.

  • Step/paw, stepping back and/or paw flick, reflecting pain sensation; Vocal/run/jump, vocalization, running and/or jumping, reflecting aversive reactions.

  • Significantly different between wild-type (WT) and CaMKIIα (K42R)-KI mice;

  • ↵a p = 0.0001 (unpaired t test); WT, n = 14; K42R, n = 16.