Regions showing significant lateralized group × session interactions for clustering coefficient
Regions | Baseline | 1d Abs | 14d Abs | ||||||
---|---|---|---|---|---|---|---|---|---|
Chamber control | Sucrose SA | Cocaine SA | Chamber control | Sucrose SA | Cocaine SA | Chamber control | Sucrose SA | Cocaine SA | |
LaA (R) | 0.29 ± 0.03 | 0.32 ± 0.04 | 0.30 ± 0.04 | 0.30 ± 0.02 | 0.40 ± 0.06 | 0.47 ± 0.06* | 0.40 ± 0.05 | 0.33 ± 0.02 | 0.34 ± 0.03 |
MeA (R) | 0.31 ± 0.03 | 0.38 ± 0.06 | 0.41 ± 0.02 | 0.32 ± 0.03 | 0.43 ± 0.04 | 0.49 ± 0.06* | 0.41 ± 0.06 | 0.27 ± 0.02 | 0.32 ± 0.04 |
DMS (L) | 0.30 ± 0.04 | 0.29 ± 0.05 | 0.39 ± 0.05 | 0.31 ± 0.05 | 0.46 ± 0.04 | 0.49 ± 0.05* | 0.44 ± 0.04 | 0.28 ± 0.02 | 0.37 ± 0.04 |
LSept (R) | 0.30 ± 0.02 | 0.29 ± 0.03 | 0.39 ± 0.04 | 0.35 ± 0.08 | 0.37 ± 0.09 | 0.56 ± 0.07* | 0.42 ± 0.04 | 0.26 ± 0.01 | 0.32 ± 0.04 |
AHA (R) | 0.28 ± 0.03 | 0.35 ± 0.03 | 0.34 ± 0.03 | 0.30 ± 0.03 | 0.49 ± 0.04* | 0.51 ± 0.07* | 0.41 ± 0.06 | 0.34 ± 0.05 | 0.36 ± 0.05 |
MB (R) | 0.28 ± 0.03 | 0.37 ± 0.05 | 0.32 ± 0.02 | 0.31 ± 0.03 | 0.41 ± 0.09 | 0.51 ± 0.09* | 0.42 ± 0.05 | 0.32 ± 0.02 | 0.36 ± 0.04 |
VM Thal (R) | 0.34 ± 0.03 | 0.43 ± 0.04 | 0.40 ± 0.03 | 0.31 ± 0.03 | 0.51 ± 0.05* | 0.52 ± 0.07* | 0.40 ± 0.06 | 0.28 ± 0.04 | 0.36 ± 0.03 |
PThal (R) | 0.34 ± 0.03 | 0.36 ± 0.07 | 0.38 ± 0.03 | 0.32 ± 0.03 | 0.45 ± 0.08 | 0.47 ± 0.04* | 0.35 ± 0.03 | 0.29 ± 0.02 | 0.33 ± 0.03 |
MG Thal (L) | 0.31 ± 0.02 | 0.38 ± 0.04 | 0.41 ± 0.04 | 0.36 ± 0.07 | 0.45 ± 0.05 | 0.52 ± 0.05 | 0.45 ± 0.09 | 0.38 ± 0.04 | 0.35 ± 0.04 |
cRSC (L) | 0.39 ± 0.04 | 0.34 ± 0.03 | 0.35 ± 0.05 | 0.38 ± 0.05 | 0.60 ± 0.07* | 0.51 ± 0.05 | 0.46 ± 0.04 | 0.36 ± 0.05 | 0.36 ± 0.02 |
M1 (L) | 0.26 ± 0.02 | 0.29 ± 0.02 | 0.29 ± 0.03 | 0.31 ± 0.04 | 0.40 ± 0.07 | 0.38 ± 0.05 | 0.45 ± 0.05 | 0.32 ± 0.02 | 0.33 ± 0.04 |
S1 Tr (R) | 0.31 ± 0.03 | 0.44 ± 0.09 | 0.40 ± 0.06 | 0.26 ± 0.04 | 0.43 ± 0.07 | 0.48 ± 0.06* | 0.48 ± 0.09 | 0.38 ± 0.03 | 0.32 ± 0.02 |
PRhC (L) | 0.30 ± 0.02 | 0.27 ± 0.04 | 0.30 ± 0.03 | 0.34 ± 0.02 | 0.60 ± 0.10* | 0.41 ± 0.04** | 0.39 ± 0.05 | 0.28 ± 0.02 | 0.36 ± 0.04 |
MRN (L) | 0.35 ± 0.03 | 0.35 ± 0.05 | 0.38 ± 0.04 | 0.37 ± 0.04 | 0.44 ± 0.03 | 0.53 ± 0.04* | 0.38 ± 0.03 | 0.43 ± 0.03 | 0.34 ± 0.03 |
Cer2 (L) | 0.38 ± 0.04 | 0.39 ± 0.04 | 0.33 ± 0.02 | 0.33 ± 0.05 | 0.49 ± 0.02* | 0.46 ± 0.05* | 0.51 ± 0.05 | 0.32 ± 0.02* | 0.35 ± 0.03* |
Data are shown as the mean ± SEM for sucrose or cocaine SA rats and chamber exposure controls at baseline, 1d Abs, and 14d Abs. R, Right; L, left; LaA, lateral amygdala; MeA, medial amygdala; DMS, dorsomedial striatum; LSept, lateral septum; AHA, anterior hypothalamic area; MB, mammillary bodies; Thal, thalamus; VM, ventromedial; Pthal, posterior thalamus; MG, medial genticulate; cRSC, caudal retrosplenial cortex; M1, primary motor cortex; S1, primary somatosensory cortex; Tr, trunk region; PRhC, perirhinal cortex; MRN, midbrain reticular nucleus; Cer2, 2nd cerebellar lobule. All regions in table showed significant group x session interactions with a repeated-measures two factor ANOVA (α < 0.05).
Asterisks represent results of Tukey’s multiple-comparison post hoc test: *difference from chamber exposure controls; **difference between cocaine and sucrose groups..