Table 1.

Details of statistical analyses presented in the article

FiguresExperimentn(N)Test usedp valueMean (CI)*
1AIn vitro, interface, P55WT: 10(3), KO: 9(3)ANOVA0.0025see 1Bleft
1BLeft: in vitro, interface, P55WT: 10(3), KO: 9(3)Two-way ANOVAExperimental condition: 0.89
genotype: <0.0001
WT: 38.3 (18.2), KO: 76.4 (12.0)
Right: in vitro, submerged, P25WT: 30(5), KO: 34(6)WT: 37.6 (6.1), KO: 56.3 (6.9)
1CLeft: in vitro, interface, P25WT: 4(2), KO: 4(2)Two-way ANOVAExperimental condition: 0.98
genotype: 0.0005
WT: 1.00 (0.31), KO: 0.67 (0.29)
Middle: in vitro, submerged, P25WT: 8(3), KO: 11(4)WT: 1.00 (0.24), KO: 0.71 (0.14)
Right: in vitro, interface, P85WT: 9(3), KO: 9(3)WT: 1.00 (0.20), KO: 0.69 (0.12)
1D*Left: in vitro, submerged, P25WT: 18(8), KO: 19(6)Mann–Whitney U0.013WT: 1.0 [0.8 1.4], KO: 0.7 [0.6 0.9]
Middle: in vitro, submerged, P25WT: 20(6), KO: 18(8)Mann–Whitney U0.036WT: 1.0 [0.6 1.2], KO: 0.5 [0.4 1.1]
Right: in vitro, interface, P25WT: 12(2), KO: 12(2)Mann–Whitney U0.29WT: 1.0 [0.5 1.3], KO: 1.2 [0.7 1.7]
2AIn vivo, P50, 3h-LTPWT: 16, KO: 15For LTP induction: two-way ANOVALTP (categorical): WT: 0.017, KO: <0.0001
time (continuous): WT: 0.42, KO: 0.005
LTP 2-3h postinduction (%):
WT: 9.1 (8.6), KO: 32.6 (25.5)
Between genotypes: two-way ANOVAgenotype: <0.0001
time: 0.016
2BIn vivo, P50, 2h-LTPWT: 16, KO: 16For LTP induction: two-way ANOVALTP (categorical): WT: <0.0001, KO: 0.002
time (continuous): WT: 0.02, KO: 0.15
LTP 1-2h postinduction (%):
WT: 15.0 (6.9), KO: 15.0 (12.1)
Between genotypes: two-way ANOVAGenotype: 0.82
time: 0.048
2CIn vivo, P50WT: 12, KO: 8Two-way ANOVAGenotype: 0.011 stimulation: <0.0001WT125μA: 1.9 (1.1),
KO125μA: 1.1 (0.5)
3AIn vivo, P50, L-LTPWT: 10, KO: 10For LTP induction: two-way ANOVALTP (categorical): WT: <0.0001, KO: 0.012
time (continuous): WT: 0.007, KO: 0.74
LTP 2-3h postinduction (%):
WT: 12.9 (11.2), KO: 14.3 (12.0)
Between genotypes: two-way ANOVAGenotype: 0.79
time: 0.17
3BIn vivo, P50, E-LTPWT: 10, KO: 10For LTP induction: two-way ANOVALTP (categorical): WT: 0.0002, KO: <0.0001
time (continuous): WT: 0.022, KO: 0.003
LTP 1-2h postinduction (%):
WT: 12.0 (18.6), KO: 10.6 (13.2)
Between genotypes: two-way ANOVAGenotype: 0.16
time: 0.006
3CIn vivo, P50WT: 5, KO: 5Two-way ANOVAGenotype: 0.94 stimulation: <0.0001WT125μA: 2.2 (1.9), KO125μA: 1.7 (1.4)
4AIn vitro, submerged, P25WT: 11(6)Student’s t test (paired)WT: 0.19WT−60mV: 16.3 (6.6), WT+40mV: 13.2 (5.6)
KO: 14(6)Student’s t test (paired)KO: 0.0003KO−60mV: 36.3 (10.9), KO+40mV: 12.7 (4.1)
4CIn vitro, submerged, P25WT: 11(6), KO: 13(6)Student’s t test0.0018WT: 3.1 (4.4), KO: 23.6 (9.4)
4D*In vitro, submerged, P25WT: 20(6), KO: 18(8)Mann–Whitney U0.036WT: 1.9 [1.1 2.3], KO: 0.9 [0.7 2.0]
4EIn vitro, submerged, AMPA/NMDA ratio*P13–P14: WT: 16(4) KO: 18(5)
P21–P24: WT: 10(3), KO: 11(3)
P25–P28: WT: 10(4), KO: 7(3)
Over age groups: Kruskal–Wallis testWT: 0.0026, KO: 0.056P13–P14: WT: 0.68 [0.47 0.88], KO: 0.45 [0.31 0.64]
P21–P24: WT: 0.75 [0.55 1.09], KO: 0.63 [0.43 0.93]
P25–P28: WT: 1.20 [0.88 1.48], KO: 0.78 [0.50 1.00]
Between genotypes: Mann–Whitney UP13–P14: 0.055
P21–P24: 0.083
P25–P28: 0.016
In vitro, submerged, LTPP13–P14: WT: 10(2), KO: 7(2)
P21–P24: WT: 15(2), KO: 14(2)
P25–P28: WT: 15(3), KO: 20(3)
Over age groups: ANOVAWT: 0.012, KO: 0.77P13–P14: WT: 51.6 (12.9), KO: 61.6 (11.4)
P21–P24: WT: 44.6 (7.9), KO: 58.2 (13.2)
P25–P28: WT: 30.5 (8.2), KO: 55.3 (7.8)
Between genotypes: Student’s t testP13–P14: 0.30
P21–P24: 0.09
P25–P28: 0.0002
  • * Median and percentiles [25th 75th] are reported for nonparametric datasets instead of mean and CI values.