Measure | Factor(s) | Level(s) | Data structure: normality tests Kolmogorov–Smirnov ( t test);Mauchly’s sphericity (ANOVAs) | Type of test | Statistical value | p value | Effect size: Cohen's d (t test);partial η ^{2} (ANOVA) | Observed power | |
---|---|---|---|---|---|---|---|---|---|

a | mGluR1 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = -1.670 | 0.110 | 0.740 | 0.380 |

b | mGluR5 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = 2.407 | 0.026 | 1.000 | 0.449 |

c | mGluR2/3 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = 2.366 | 0.028 | 0.928 | 0.350 |

d | mGluR4 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = 0.754 | 0.459 | 0.347 | 0.064 |

e | mGluR7 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = 1.134 | 0.270 | 0.490 | 0.192 |

f | mGluR8 protein level in whole mPFC | Age | 2 | Normal | t test (FDR-corrected) | t = -1.650 | 0.114 | 0.698 | 0.310 |

g | GRM1 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 0.261 | 0.798 | 0.129 | 0.058 |

h | GRM5 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 3.200 | 0.006 | 1.515 | 0.767 |

i | GRM2 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 1.213 | 0.243 | 0.631 | 0.209 |

j | GRM3 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 2.990 | 0.009 | 1.593 | 0.781 |

k | GRM4 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 3.058 | 0.008 | 1.509 | 0.831 |

l | GRM7 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 1.963 | 0.067 | 1.002 | 0.476 |

m | GRM8 gene expression in PrL | Age | 2 | Normal | t test (FDR-corrected) | t = 1.793 | 0.092 | 0.923 | 0.402 |

n | GRM1 gene expression in IL | Age | 2 | Non-normal | t test (FDR-corrected) | t = -0.854 | 0.406 | 0.395 | 0.103 |

o | GRM5 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.046 | 0.964 | 0.024 | 0.051 |

p | GRM2 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.228 | 0.823 | 0.121 | 0.055 |

q | GRM3 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.589 | 0.479 | 0.325 | 0.082 |

r | GRM4 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.682 | 0.505 | 0.376 | 0.093 |

s | GRM7 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.329 | 0.746 | 0.174 | 0.061 |

t | GRM8 gene expression in IL | Age | 2 | Normal | t test (FDR-corrected) | t = -0.605 | 0.554 | 0.328 | 0.085 |

u | MTEP choice accuracy (all doses) | Dose | 4 | Sphericity assumed | Repeated-measures ANOVA | F = 3.176 | 0.049 | 0.364 | 0.634 |

Dose by delay | 4*7 | Sphericity assumed | Repeated-measures ANOVA | F = 1.096 | 0.366 | 0.154 | 0.720 | ||

Delay | 7 | Sphericity assumed | Repeated- measures ANOVA | F = 87.404 | 0.000 | 0.936 | 1.000 | ||

v | MTEP choice accuracy (0.1-µg dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 2.44 | 0.639 | 0.039 | 0.070 |

Dose by delay | 2*7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 0.765 | 0.602 | 0.113 | 0.262 | ||

Delay | 7 | Sphericity assumed | Repeated- measures ANOVA | F = 56.882 | 0.000 | 0.905 | 1.000 | ||

w | MTEP choice accuracy (0.3-µg dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 54.178 | 0.000 | 0.900 | 1.000 |

Dose by delay | 2*7 | Sphericity assumed | Repeated- measures ANOVA | F = 1.388 | 0.246 | 0.188 | 0.471 | ||

Delay | 7 | Sphericity assumed | Repeated- measures ANOVA | F = 55.700 | 0.000 | 0.903 | 1.000 | ||

x | MTEP choice accuracy (1.0-µg dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 0.024 | 0.882 | 0.004 | 0.052 |

Dose by delay | 2*7 | Sphericity assumed | Repeated- measures ANOVA | F = 1.186 | 0.336 | 0.165 | 0.404 | ||

Delay | 7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 28.045 | 0.000 | 0.824 | 1.000 | ||

y | MTEP Trials | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 0.571 | 0.642 | 0.087 | 0.145 |

z | MTEP response latency (matching phase) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 2.550 | 0.088 | 0.298 | 0.531 |

aa | MTEP response latency (sample phase) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 1.149 | 0.356 | 0.161 | 0.257 |

bb | MTEP carry-over effects (washout days, all doses) | Day | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 0.239 | 0.868 | 0.038 | 0.087 |

cc | MTEP injections (all doses) | Injection | 4 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 1.205 | 0.334 | 0.167 | 0.269 |

dd | LY341495 choice accuracy (all doses) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 4.778 | 0.008 | 0.347 | 0.853 |

Dose by delay | 4*7 | Sphericity assumed | Repeated- measures ANOVA | F = 2.083 | 0.009 | 0.188 | 0.978 | ||

Delay | 7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 49.091 | 0.000 | 0.845 | 1.000 | ||

ee | LY341495 choice accuracy (5-ng dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 0.570 | 0.470 | 0.060 | 0.104 |

Dose by delay | 2*7 | Sphericity assumed | Repeated- measures ANOVA | F = 2.834 | 0.018 | 0.239 | 0.847 | ||

Delay | 7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 29.521 | 0.000 | 0.766 | 1.000 | ||

ff | LY341495 choice accuracy (50-ng dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 1.895 | 0.202 | 0.174 | 0.234 |

Dose by delay | 2*7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 2.887 | 0.029 | 0.243 | 0.855 | ||

Delay | 7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 41.188 | 0.000 | 0.821 | 1.000 | ||

gg | LY341495 choice accuracy (500-ng dose) | Dose | 2 | Sphericity assumed | Repeated- measures ANOVA | F = 14.911 | 0.004 | 0.624 | 0.929 |

Dose by delay | 2*7 | Sphericity assumed | Repeated- measures ANOVA | F = 1.793 | 0.118 | 0.166 | 0.623 | ||

Delay | 7 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 37.902 | 0.000 | 0.808 | 1.000 | ||

hh | LY341495 choice accuracy (0-s delay) | Dose | 4 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 0.617 | 0.512 | 0.064 | 0.124 |

ii | LY341495 choice accuracy (2-s delay) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 0.527 | 0.668 | 0.055 | 0.143 |

jj | LY341495 choice accuracy (4-s delay) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 0.267 | 0.848 | 0.029 | 0.094 |

kk | LY341495 choice accuracy (8-s delay) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 2.239 | 0.107 | 0.199 | 0.504 |

ll | LY341495 choice accuracy (12-s delay) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 2.911 | 0.053 | 0.244 | 0.627 |

mm | LY341495 choice accuracy (18-s delay) | Dose (all doses) | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 5.009 | 0.007 | 0.358 | 0.870 |

Dose (Veh vs 5 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = 2.501 | 0.034 | 0.945 | 0.260 | ||

Dose (Veh vs 50 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = 3.212 | 0.011 | 0.956 | 0.265 | ||

Dose (Veh vs 500 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = 2.596 | 0.029 | 1.069 | 0.318 | ||

nn | LY341495 choice accuracy (24-s delay) | Dose (all doses) | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 3.57 | 0.027 | 0.284 | 0.725 |

Dose (Veh vs 5 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = -1.041 | 0.325 | 0.364 | 0.073 | ||

Dose (Veh vs 50 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = -0.347 | 0.736 | 0.146 | 0.039 | ||

Dose (Veh vs 500 ng) | 2 | Normal | Post hoc
paired-samples t test (Dunnett-corrected) | t = 2.402 | 0.040 | 0.778 | 0.190 | ||

oo | LY341495 trials | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 2.422 | 0.088 | 0.212 | 0.540 |

pp | LY341495 response latency (matching phase) | Dose | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 1.000 | 0.408 | 0.100 | 0.242 |

LY341495 response latency (sample phase) | Dose | 4 | Sphericity violated: Huynh–Feldt corrected | Repeated- measures ANOVA | F = 2.017 | 0.185 | 0.183 | 0.460 | |

rr | LY341495 Carry-over effects (washout days, all doses) | Day | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 1.341 | 0.282 | 0.130 | 0.316 |

ss | LY341495 injections (all doses) | Injection | 4 | Sphericity assumed | Repeated- measures ANOVA | F = 0.276 | 0.842 | 0.030 | 0.096 |