Table 6.

Summary of statistical analyses

MeasureFactor(s)Level(s)Data structure: normality tests
Kolmogorov–Smirnov
(t test);
Mauchly’s sphericity (ANOVAs)
Type of testStatistical valuep valueEffect size:
Cohen's d (t test);
partial η2 (ANOVA)
Observed power
amGluR1 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = -1.6700.1100.7400.380
bmGluR5 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = 2.4070.0261.0000.449
cmGluR2/3 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = 2.3660.0280.9280.350
dmGluR4 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = 0.7540.4590.3470.064
emGluR7 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = 1.1340.2700.4900.192
fmGluR8 protein level in whole mPFCAge2Normalt test (FDR-corrected)t = -1.6500.1140.6980.310
gGRM1 gene expression in PrLAge2Normalt test (FDR-corrected)t = 0.2610.7980.1290.058
hGRM5 gene expression in PrLAge2Normalt test (FDR-corrected)t = 3.2000.0061.5150.767
iGRM2 gene expression in PrLAge2Normalt test (FDR-corrected)t = 1.2130.2430.6310.209
jGRM3 gene expression in PrLAge2Normalt test (FDR-corrected)t = 2.9900.0091.5930.781
kGRM4 gene expression in PrLAge2Normalt test (FDR-corrected)t = 3.0580.0081.5090.831
lGRM7 gene expression in PrLAge2Normalt test (FDR-corrected)t = 1.9630.0671.0020.476
mGRM8 gene expression in PrLAge2Normalt test (FDR-corrected)t = 1.7930.0920.9230.402
nGRM1 gene expression in ILAge2Non-normalt test (FDR-corrected)t = -0.8540.4060.3950.103
oGRM5 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.0460.9640.0240.051
pGRM2 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.2280.8230.1210.055
qGRM3 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.5890.4790.3250.082
rGRM4 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.6820.5050.3760.093
sGRM7 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.3290.7460.1740.061
tGRM8 gene expression in ILAge2Normalt test (FDR-corrected)t = -0.6050.5540.3280.085
uMTEP choice accuracy (all doses)Dose4Sphericity assumedRepeated-measures ANOVAF = 3.1760.0490.3640.634
Dose by delay4*7Sphericity assumedRepeated-measures ANOVAF = 1.0960.3660.1540.720
Delay7Sphericity assumedRepeated- measures ANOVAF = 87.4040.0000.9361.000
vMTEP choice accuracy (0.1-µg dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 2.440.6390.0390.070
Dose by delay2*7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 0.7650.6020.1130.262
Delay7Sphericity assumedRepeated- measures ANOVAF = 56.8820.0000.9051.000
wMTEP choice accuracy (0.3-µg dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 54.1780.0000.9001.000
Dose by delay2*7Sphericity assumedRepeated- measures ANOVAF = 1.3880.2460.1880.471
Delay7Sphericity assumedRepeated- measures ANOVAF = 55.7000.0000.9031.000
xMTEP choice accuracy (1.0-µg dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 0.0240.8820.0040.052
Dose by delay2*7Sphericity assumedRepeated- measures ANOVAF = 1.1860.3360.1650.404
Delay7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 28.0450.0000.8241.000
yMTEP TrialsDose4Sphericity assumedRepeated- measures ANOVAF = 0.5710.6420.0870.145
zMTEP response latency (matching phase)Dose4Sphericity assumedRepeated- measures ANOVAF = 2.5500.0880.2980.531
aaMTEP response latency (sample phase)Dose4Sphericity assumedRepeated- measures ANOVAF = 1.1490.3560.1610.257
bbMTEP carry-over effects (washout days, all doses)Day4Sphericity assumedRepeated- measures ANOVAF = 0.2390.8680.0380.087
ccMTEP injections (all doses)Injection4Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 1.2050.3340.1670.269
ddLY341495 choice accuracy (all doses)Dose4Sphericity assumedRepeated- measures ANOVAF = 4.7780.0080.3470.853
Dose by delay4*7Sphericity assumedRepeated- measures ANOVAF = 2.0830.0090.1880.978
Delay7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 49.0910.0000.8451.000
eeLY341495 choice accuracy (5-ng dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 0.5700.4700.0600.104
Dose by delay2*7Sphericity assumedRepeated- measures ANOVAF = 2.8340.0180.2390.847
Delay7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 29.5210.0000.7661.000
ffLY341495 choice accuracy (50-ng dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 1.8950.2020.1740.234
Dose by delay2*7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 2.8870.0290.2430.855
Delay7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 41.1880.0000.8211.000
ggLY341495 choice accuracy (500-ng dose)Dose2Sphericity assumedRepeated- measures ANOVAF = 14.9110.0040.6240.929
Dose by delay2*7Sphericity assumedRepeated- measures ANOVAF = 1.7930.1180.1660.623
Delay7Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 37.9020.0000.8081.000
hhLY341495 choice accuracy (0-s delay)Dose4Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 0.6170.5120.0640.124
iiLY341495 choice accuracy (2-s delay)Dose4Sphericity assumedRepeated- measures ANOVAF = 0.5270.6680.0550.143
jjLY341495 choice accuracy (4-s delay)Dose4Sphericity assumedRepeated- measures ANOVAF = 0.2670.8480.0290.094
kkLY341495 choice accuracy (8-s delay)Dose4Sphericity assumedRepeated- measures ANOVAF = 2.2390.1070.1990.504
llLY341495 choice accuracy (12-s delay)Dose4Sphericity assumedRepeated- measures ANOVAF = 2.9110.0530.2440.627
mmLY341495 choice accuracy (18-s delay)Dose (all doses)4Sphericity assumedRepeated- measures ANOVAF = 5.0090.0070.3580.870
Dose (Veh vs 5 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = 2.5010.0340.9450.260
Dose (Veh vs 50 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = 3.2120.0110.9560.265
Dose (Veh vs 500 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = 2.5960.0291.0690.318
nnLY341495 choice accuracy (24-s delay)Dose (all doses)4Sphericity assumedRepeated- measures ANOVAF = 3.570.0270.2840.725
Dose (Veh vs 5 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = -1.0410.3250.3640.073
Dose (Veh vs 50 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = -0.3470.7360.1460.039
Dose (Veh vs 500 ng)2NormalPost hoc paired-samples t test (Dunnett-corrected)t = 2.4020.0400.7780.190
ooLY341495 trialsDose4Sphericity assumedRepeated- measures ANOVAF = 2.4220.0880.2120.540
ppLY341495 response latency (matching phase)Dose4Sphericity assumedRepeated- measures ANOVAF = 1.0000.4080.1000.242
qqLY341495 response latency (sample phase)Dose4Sphericity violated: Huynh–Feldt correctedRepeated- measures ANOVAF = 2.0170.1850.1830.460
rrLY341495 Carry-over effects (washout days, all doses)Day4Sphericity assumedRepeated- measures ANOVAF = 1.3410.2820.1300.316
ssLY341495 injections (all doses)Injection4Sphericity assumedRepeated- measures ANOVAF = 0.2760.8420.0300.096